ENSMUSG00000020383


Mus musculus

Features
Gene ID: ENSMUSG00000020383
  
Biological name :Il13
  
Synonyms : Il13 / Interleukin-13 / P20109
  
Possible biological names infered from orthology : P35225
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 53631324
Gene end: 53634702
  
Corresponding Affymetrix probe sets: 10385837 (MoGene1.0st)   1420802_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020650
NCBI entrez gene - 16163     See in Manteia.
MGI - MGI:96541
RefSeq - NM_008355
RefSeq Peptide - NP_032381
swissprot - P20109
Ensembl - ENSMUSG00000020383
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL13ENSG00000169194Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001325  Interleukin-4/interleukin-13
 IPR009079  Four-helical cytokine-like, core
 IPR018096  Interleukin-4/interleukin-13, conserved site
 IPR020470  Interleukin-13


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002639 positive regulation of immunoglobulin production IMP
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0043032 positive regulation of macrophage activation IMP
 biological_processGO:0043306 positive regulation of mast cell degranulation IMP
 biological_processGO:0071345 cellular response to cytokine stimulus IDA
 biological_processGO:1903660 negative regulation of complement-dependent cytotoxicity IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: C.129P2-Il13tm1.1Anjm

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13tm1Anjm,Il5tm3Anjm/Il5tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002531 type I hypersensitivity reaction "a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm3.1Anjm/Il13+,Il17rbtm1Anjm/Il17rbtm1Anjm
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Il13tm3.1Anjm/Il13+,Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Il13tm1(YFP/cre)Lky/Il13+,Il4tm1(CD2)Mmrs/Il4+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Il13tm1(YFP/cre)Lky/Il13+
Genetic Background: involves: 129S4/SvJae

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13tm1Anjm,Il5tm3Anjm/Il5tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Il13tm1(YFP/cre)Lky/Il13+,Il4tm1(CD2)Mmrs/Il4+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Il13tm1(YFP/cre)Lky/Il13+
Genetic Background: involves: 129S4/SvJae

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: C.129P2-Il13tm1.1Anjm

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008091 decreased T-helper 2 cell number "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: C.129P2-Il13tm1.1Anjm

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: C.129P2-Il13tm1.1Anjm

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: C.129P2-Il13tm1.1Anjm

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008609 decreased circulating interleukin-13 level "reduction in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il4tm1.1Wep/Il4+
Genetic Background: C.129P2-Il4tm1.1Wep

Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: C.129P2-Il13tm1.1Anjm

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008698 abnormal interleukin-4 secretion "anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: C.129P2-Il13tm1Anjm

Allelic Composition: Il13tm1Anjm/Il13+,Il4tm1.1Wep/Il4+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

Allelic Composition: Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic Background: C.129P2-Il13tm1.1Anjm

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008712 decreased interleukin-9 secretion "reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Il13tm1Anjm/Il13tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tg(SFTPC-Il18)AThos/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / complex / reaction
 ENSMUSG00000031289 O88786 / Il13ra2 / Interleukin-13 receptor subunit alpha-2 / Q14627*  / complex / reaction
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex






 

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