ENSMUSG00000004040


Mus musculus

Features
Gene ID: ENSMUSG00000004040
  
Biological name :Stat3
  
Synonyms : P42227 / Signal transducer and activator of transcription 3 / Stat3
  
Possible biological names infered from orthology : P40763
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100885098
Gene end: 100939540
  
Corresponding Affymetrix probe sets: 10391301 (MoGene1.0st)   1424272_at (Mouse Genome 430 2.0 Array)   1426587_a_at (Mouse Genome 430 2.0 Array)   1459961_a_at (Mouse Genome 430 2.0 Array)   1460700_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090342
Ensembl peptide - ENSMUSP00000099403
Ensembl peptide - ENSMUSP00000120152
Ensembl peptide - ENSMUSP00000121677
NCBI entrez gene - 20848     See in Manteia.
MGI - MGI:103038
RefSeq - XM_017314401
RefSeq - NM_011486
RefSeq - NM_213659
RefSeq - NM_213660
RefSeq - XM_011248846
RefSeq Peptide - NP_998824
RefSeq Peptide - NP_998825
RefSeq Peptide - NP_035616
swissprot - P42227
swissprot - Q6GU23
swissprot - B7ZC18
Ensembl - ENSMUSG00000004040
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat3ENSDARG00000022712Danio rerio
 STAT3ENSGALG00000003267Gallus gallus
 STAT3ENSG00000168610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stat1 / signal transducer and activator of transcription 1 / P42224*ENSMUSG0000002610452
Stat4 / signal transducer and activator of transcription 4 / Q14765*ENSMUSG0000006293947
Stat2 / signal transducer and activator of transcription 2 / P52630*ENSMUSG0000004003338
P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*ENSMUSG0000002091929
P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*ENSMUSG0000000404328
Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*ENSMUSG0000000214723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR035855  STAT3, SH2 domain
 IPR036535  STAT transcription factor, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0001754 eye photoreceptor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0006606 protein import into nucleus ISS
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010730 negative regulation of hydrogen peroxide biosynthetic process IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016310 phosphorylation IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway NAS
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0019953 sexual reproduction IMP
 biological_processGO:0030522 intracellular receptor signaling pathway ISO
 biological_processGO:0032355 response to estradiol ISO
 biological_processGO:0032870 cellular response to hormone stimulus ISO
 biological_processGO:0033210 leptin-mediated signaling pathway ISO
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation ISO
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042755 eating behavior IMP
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0044320 cellular response to leptin stimulus ISO
 biological_processGO:0044321 response to leptin ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation ISS
 biological_processGO:0045747 positive regulation of Notch signaling pathway IMP
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045820 negative regulation of glycolytic process IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0048708 astrocyte differentiation IMP
 biological_processGO:0051726 regulation of cell cycle ISS
 biological_processGO:0055091 phospholipid homeostasis IMP
 biological_processGO:0060019 radial glial cell differentiation IMP
 biological_processGO:0060259 regulation of feeding behavior IMP
 biological_processGO:0060396 growth hormone receptor signaling pathway ISO
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway IDA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway ISO
 biological_processGO:0071345 cellular response to cytokine stimulus ISO
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 biological_processGO:0072540 T-helper 17 cell lineage commitment IMP
 biological_processGO:0097009 energy homeostasis IMP
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:1904685 positive regulation of metalloendopeptidase activity ISO
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IDA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA ISO
 biological_processGO:2000737 negative regulation of stem cell differentiation IMP
 biological_processGO:2001171 positive regulation of ATP biosynthetic process IEA
 biological_processGO:2001223 negative regulation of neuron migration IGI
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004879 nuclear receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0031490 chromatin DNA binding ISS
 molecular_functionGO:0031730 CCR5 chemokine receptor binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046983 protein dimerization activity IPI


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Downstream signal transduction
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Samd8tm1Jia/Samd8tm1Jia,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Samd8tm1Jia/Samd8tm1Jia,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0000494 abnormal cecum morphology "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Dlx3tm2Mso/Dlx3tm3Mso,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Samd8tm1Jia/Samd8tm1Jia,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Stat3tm1Vpo/Stat3tm1Vpo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0002314 abnormal respiratory mechanics "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0002378 abnormal gut-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pigatm2Tak/Y
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stat3tm1Vpo/Stat3tm2Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * BALB/cAn

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Samd8tm1Jia/Samd8tm1Jia,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Stat3tm1Vpo/Stat3tm1Vpo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002963 decreased protein excretion "less than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Stat3tm1Xyfu/Stat3+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0003795 abnormal bone structure 
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Stat3tm1Vpo/Stat3tm1Vpo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0004700 abnormal circulating insulin-like growth factor I level "anomalous blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcirg1oc/Tcirg1oc
Genetic Background: C57BL/6J-Vps33abf

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Stat3tm1Vpo/Stat3+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Stat3tm1Vpo/Stat3+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1oc/Tcirg1oc
Genetic Background: C57BL/6J-Vps33abf

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Stat3tm1Vpo/Stat3+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pigatm2Tak/Y
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Stat3tm1Vpo/Stat3tm2Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * BALB/cAn

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm1Xyfu/Stat3tm1.1Xyfu,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Stat3tm1Xyfu/Stat3+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Stat3tm1Vpo/Stat3tm2Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * BALB/cAn

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Stat3tm1Aki/Stat3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Stat3tm1Xyfu/Stat3tm1.1Xyfu,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Stat3tm1Xyfu/Stat3+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Rorctm1Amj/Rorctm1Amj
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Xyfu/Stat3tm1.1Xyfu,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009089 short uterine horn "length reduction or truncation of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Stat3tm1Xyfu/Stat3tm1.1Xyfu,Tg(Ttr-cre)10-3Xyfu/?
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Stat3tm1Jbha/Stat3tm1Jbha,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Xyfu/Stat3tm1.1Xyfu,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0010811 decreased type II pneumocyte number "reduced number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0010858 pulmonary epithelial necrosis "pathological cell death in the lung epithelium, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0010896 decreased lung compliance "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0011018 pulmonary hyaline membrane formation "abnormal presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles; hyaline membranes block gas exchange and are usually found at autopsy in individuals that have died of respiratory distress syndrome in the neonatal stages" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0011044 increased lung elastance "faster ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0011047 increased lung tissue damping "increased value of the respiratory mechanical parameter (G) that is closely related to tissue resistance and reflects the energy dissipation in the lung tissues" [MGI:anna]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nphs2tm1Antc/Nphs2tm1Antc
Genetic Background: 129-Nphs2tm1Antc

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0012113 decreased inner cell mass proliferation 
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0013807 generalized edema "generalized abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body" [HP:0007430, HPO:curators]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Stat3tm1Vpo/Stat3+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0020447 decreased NAD(P)H oxidase activity "reduced ability to catalyze the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide" [GO:0016174]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction / complex
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / reaction / complex
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / reaction / complex
 ENSMUSG00000020279 Il9r / Q01114 / Interleukin-9 receptor / Q01113*  / complex / reaction
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000020007 Il20ra / Q6PHB0 / interleukin 20 receptor, alpha / Q9UHF4* / interleukin 20 receptor subunit alpha*  / complex
 ENSMUSG00000016529 Il10 / P18893 / Interleukin-10 / P22301*  / reaction / complex
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000021538 Il9 / P15247 / Interleukin-9 / P15248*  / complex / reaction
 ENSMUSG00000026416 Il20 / Q9JKV9 / interleukin 20 / Q9NYY1*  / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000032089 Il10ra / Q61727 / Interleukin-10 receptor subunit alpha / Q13651*  / complex / reaction
 ENSMUSG00000057722 Lepr / P48356 / Leptin receptor / P48357*  / complex / reaction
 ENSMUSG00000038781 Stap2 / Q8R0L1 / Signal-transducing adaptor protein 2 / Q9UGK3* / signal transducing adaptor family member 2*  / complex / reaction
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / complex / reaction
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex
 ENSMUSG00000059201 Lep / P41160 / Leptin / P41159*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000074695 Il22 / Q9JJY9 / Interleukin-22 / Q9GZX6*  / complex
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / complex
 ENSMUSG00000033467 Crlf2 / cytokine receptor-like factor 2 isoform 1 / Q9HC73* / cytokine receptor like factor 2*  / complex
 ENSMUSG00000037157 Q80XZ4 / Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q8N6P7*  / complex
 ENSMUSG00000025383 Il23a / Q9EQ14 / Interleukin-23 subunit alpha / Q9NPF7*  / complex
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex / reaction
 ENSMUSG00000049093 Il23r / interleukin 23 receptor / Q5VWK5*  / complex
 ENSMUSG00000044244 Il20rb / interleukin 20 receptor subunit beta / Q6UXL0*  / complex
 ENSMUSG00000026420 Il24 / interleukin 24 / Q13007*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / reaction / complex
 ENSMUSG00000016524 Il19 / Q8CJ70 / Interleukin-19 / Q9UHD0*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex
 ENSMUSG00000025746 Il6 / P08505 / interleukin 6 / P05231*  / complex / reaction
 ENSMUSG00000020383 Il13 / P20109 / Interleukin-13 / P35225*  / complex / reaction
 ENSMUSG00000027947 Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*  / reaction / complex
 ENSMUSG00000030745 Il21r / Q9JHX3 / Interleukin-21 receptor / Q9HBE5*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / complex
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / complex
 ENSMUSG00000024379 Tslp / Q9JIE6 / Thymic stromal lymphopoietin / Q969D9*  / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / reaction / complex
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex
 ENSMUSG00000027718 Il21 / Q9ES17 / Interleukin-21 / Q9HBE4*  / complex
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / reaction / complex
 ENSMUSG00000090461 Q9JJY8 / Iltifb / Interleukin-22b / IL22* / Q9GZX6* / interleukin 22*  / complex






 

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