ENSMUSG00000016529


Mus musculus

Features
Gene ID: ENSMUSG00000016529
  
Biological name :Il10
  
Synonyms : Il10 / Interleukin-10 / P18893
  
Possible biological names infered from orthology : P22301
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 131019845
Gene end: 131024974
  
Corresponding Affymetrix probe sets: 10349603 (MoGene1.0st)   1450330_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016673
NCBI entrez gene - 16153     See in Manteia.
MGI - MGI:96537
RefSeq - NM_010548
RefSeq Peptide - NP_034678
swissprot - P18893
Ensembl - ENSMUSG00000016529
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il10ENSDARG00000078147Danio rerio
 IL10ENSGALG00000000892Gallus gallus
 IL10ENSG00000136634Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000098  Interleukin-10
 IPR009079  Four-helical cytokine-like, core
 IPR020423  Interleukin-10, conserved site
 IPR020443  Interleukin-10/19/20/22/24/26 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IGI
 biological_processGO:0002237 response to molecule of bacterial origin IEA
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus IMP
 biological_processGO:0002904 positive regulation of B cell apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0014854 response to inactivity IEA
 biological_processGO:0030886 negative regulation of myeloid dendritic cell activation IMP
 biological_processGO:0030889 negative regulation of B cell proliferation ISO
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032695 negative regulation of interleukin-12 production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032800 receptor biosynthetic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IGI
 biological_processGO:0034465 response to carbon monoxide IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042536 negative regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0042832 defense response to protozoan IDA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IDA
 biological_processGO:0045787 positive regulation of cell cycle IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050807 regulation of synapse organization IEA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060302 negative regulation of cytokine activity IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1903034 regulation of response to wounding IMP
 biological_processGO:1903208 negative regulation of hydrogen peroxide-induced neuron death IGI
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IMP
 biological_processGO:1904057 negative regulation of sensory perception of pain IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IGI
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IMP
 molecular_functionGO:0005141 interleukin-10 receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000199 abnormal circulating albumin level "aberrant concentration in the blood of this most abundant of the plasma proteins " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000216 absent erythrocyte precursors "lack of progenitors of the erythrocyte lineage" [J:23061]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tg(Vil1-cre)997Gum/?,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,sao/sao
Genetic Background: NOD.Cg-Il10tm1Cgn sao

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vipas39tm1c(KOMP)Mbp/Vipas39tm1c(KOMP)Mbp,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,sao/sao
Genetic Background: NOD.Cg-Il10tm1Cgn sao

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Vipas39tm1c(KOMP)Mbp/Vipas39tm1c(KOMP)Mbp,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal
Genetic Background: C57BL/6-Cd3etm1Mal

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal
Genetic Background: C57BL/6-Cd3etm1Mal

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Il10tm2Roer/Il10tm2Roer,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm2Roer/Il10tm2Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm1Mhry/Il10tm1Mhry
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tg(Vil1-cre)997Gum/?,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0002148 immune system: hypersensitivity "immune response that results in tissue injury" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm1Flv/Il10tm1Flv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Il10tm1.1Karp/Il10tm1.1Karp
Genetic Background: involves: C57BL/6

Allelic Composition: Il10tm1Hbo/Il10tm1Hbo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Il10tm2Hbo/Il10tm2Hbo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tg(Vil1-cre)997Gum/?,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm2Roer/Il10tm2Roer,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: 129S.Cg-Il10tm1Cgn

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003434 resistance to induced choroidal neovascularization "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0004504 decreased incidence of UV-induced tumors "lower than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004752 decreased length of allograft survival "compared to controls, a reduced length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B10.129P2(B6)-Il10tm1Cgn/J

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1.1Karp/Il10tm1.1Karp
Genetic Background: involves: C57BL/6

Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005046 failure of spleen white pulp formation "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0008121 increased myeloid dendritic cell number "greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0008387 hypochromic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008594 decreased circulating interleukin-10 level "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0008595 abnormal circulating interleukin-6 level "anomaly in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic Background: Not Specified

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008638 increased circulating interleukin-1 alpha level "increase in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008646 abnormal circulating interleukin-12b level "anomaly in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic Background: Not Specified

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

Allelic Composition: Il10tm1Keny/Il10+,Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic Background: involves: 129 * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008666 increased interleukin-12a secretion "increase in the production or release of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il10tm2Roer/Il10tm2Roer,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm2Roer/Il10tm2Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009310 large intestine adenocarcinoma "malignant neoplasm of epithelial cells in the large intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009816 increased leukotriene level "increased concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Tg(Vil1-cre)997Gum/?,Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010962 decreased compact bone mass 
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0011520 increased placental labyrinth size "increase in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0030466 alveolar process atrophy "acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000016529 Il10 / P18893 / Interleukin-10 / P22301*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000032089 Il10ra / Q61727 / Interleukin-10 receptor subunit alpha / Q13651*  / complex / reaction






 

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