ENSMUSG00000032175


Mus musculus

Features
Gene ID: ENSMUSG00000032175
  
Biological name :Tyk2
  
Synonyms : Tyk2 / tyrosine kinase 2
  
Possible biological names infered from orthology : P29597
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21104068
Gene end: 21131243
  
Corresponding Affymetrix probe sets: 10591446 (MoGene1.0st)   1417306_at (Mouse Genome 430 2.0 Array)   1432576_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151194
Ensembl peptide - ENSMUSP00000001036
Ensembl peptide - ENSMUSP00000150214
Ensembl peptide - ENSMUSP00000150354
NCBI entrez gene - 54721     See in Manteia.
MGI - MGI:1929470
RefSeq - XM_011242579
RefSeq - NM_001205312
RefSeq - NM_018793
RefSeq - XM_006510492
RefSeq - XM_006510493
RefSeq Peptide - NP_061263
RefSeq Peptide - NP_001192241
swissprot - E9QJS1
swissprot - Q3TXE3
swissprot - A0A1L1SVI6
Ensembl - ENSMUSG00000032175
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tyk2ENSDARG00000020326Danio rerio
 TYK2ENSG00000105397Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jak1 / Janus kinase 1 / P23458*ENSMUSG0000002853043
Jak2 / Janus kinase 2 / O60674*ENSMUSG0000002478936
Jak3 / Janus kinase 3 / P52333*ENSMUSG0000003180536


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016045  Tyrosine-protein kinase, non-receptor, TYK2, N-terminal
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035963  FERM superfamily, second domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005131 growth hormone receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm6atm1a(EUCOMM)Jhha/Kdm6atm1b(EUCOMM)Jhha,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdm6atm1a(EUCOMM)Jhha/Kdm6atm1b(EUCOMM)Jhha,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm6atm1a(EUCOMM)Jhha/Kdm6atm1b(EUCOMM)Jhha,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tyk2E775K/Tyk2E775K
Genetic Background: B10.D1-H2q/SgJ

Allelic Composition: Tyk2tm1Biat/Tyk2tm1Biat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Tyk2E775K/Tyk2E775K
Genetic Background: B10.D1-H2q/SgJ

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyk2tm1Biat/Tyk2tm1Biat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tyk2tm3.1Biat/Tyk2tm3.1Biat
Genetic Background: B6NCrl.129P2(C)-Tyk2tm3.1Biat

Allelic Composition: Tyk2tm1Biat/Tyk2tm1Biat
Genetic Background: B6NCrl.129P2-Tyk2tm1Biat

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0011077 decreased macrophage nitric oxide production "reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyk2tm1Biat/Tyk2tm1Biat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex / reaction
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / complex / reaction
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / reaction / complex
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / complex / reaction
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction / complex
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / complex / reaction
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / reaction / complex
 ENSMUSG00000025383 Il23a / Q9EQ14 / Interleukin-23 subunit alpha / Q9NPF7*  / complex
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / complex
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / reaction / complex
 ENSMUSG00000059128 Ifnl2 / Q4VK74 / Interferon lambda-2 / IFNL3* / Q8IZJ0* / Q8IZI9* / interferon lambda 3*  / complex
 ENSMUSG00000060747 Ifnl3 / Q8CGK6 / Interferon lambda-3 / IFNL2* / Q8IZI9* / Q8IZJ0* / interferon lambda 2*  / complex
 ENSMUSG00000049093 Il23r / interleukin 23 receptor / Q5VWK5*  / complex
 ENSMUSG00000016529 Il10 / P18893 / Interleukin-10 / P22301*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000037104 Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / complex
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / reaction / complex
 ENSMUSG00000032089 Il10ra / Q61727 / Interleukin-10 receptor subunit alpha / Q13651*  / complex / reaction
 ENSMUSG00000020007 Il20ra / Q6PHB0 / interleukin 20 receptor, alpha / Q9UHF4* / interleukin 20 receptor subunit alpha*  / complex
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000020383 Il13 / P20109 / Interleukin-13 / P35225*  / complex / reaction
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / complex
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex / reaction
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / reaction / complex
 ENSMUSG00000062157 Ifnlr1 / Q8CGK5 / Interferon lambda receptor 1 / Q8IU57*  / complex
 ENSMUSG00000074695 Il22 / Q9JJY9 / Interleukin-22 / Q9GZX6*  / reaction / complex
 ENSMUSG00000037157 Q80XZ4 / Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q8N6P7*  / complex / reaction
 ENSMUSG00000090461 Q9JJY8 / Iltifb / Interleukin-22b / IL22* / Q9GZX6* / interleukin 22*  / complex / reaction






 

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