ENSMUSG00000004296


Mus musculus

Features
Gene ID: ENSMUSG00000004296
  
Biological name :Il12b
  
Synonyms : Il12b / Interleukin-12 subunit beta / P43432
  
Possible biological names infered from orthology : interleukin 12B / P29460
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.1
Gene start: 44400063
Gene end: 44414033
  
Corresponding Affymetrix probe sets: 10375331 (MoGene1.0st)   1419530_at (Mouse Genome 430 2.0 Array)   1449497_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099860
Ensembl peptide - ENSMUSP00000125867
NCBI entrez gene - 16160     See in Manteia.
MGI - MGI:96540
RefSeq - NM_001303244
RefSeq Peptide - NP_001290173
swissprot - P43432
swissprot - Q3ZAX5
Ensembl - ENSMUSG00000004296
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il12baENSDARG00000033727Danio rerio
 il12bbENSDARG00000054542Danio rerio
 IL12BENSGALG00000001409Gallus gallus
 IL12BENSG00000113302Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003530  Long hematopoietin receptor, soluble alpha chain, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015528  Interleukin-12 beta
 IPR019482  Interleukin-12 beta, central domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IDA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002323 natural killer cell activation involved in immune response IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
 biological_processGO:0002862 negative regulation of inflammatory response to antigenic stimulus IMP
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010224 response to UV-B IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010536 positive regulation of activation of Janus kinase activity IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0030101 natural killer cell activation IEA
 biological_processGO:0032609 interferon-gamma production IGI
 biological_processGO:0032693 negative regulation of interleukin-10 production IEA
 biological_processGO:0032700 negative regulation of interleukin-17 production IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032740 positive regulation of interleukin-17 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032816 positive regulation of natural killer cell activation IEA
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IEA
 biological_processGO:0032946 positive regulation of mononuclear cell proliferation IEA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035744 T-helper 1 cell cytokine production IGI
 biological_processGO:0042093 T-helper cell differentiation IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0051135 positive regulation of NK T cell activation IEA
 biological_processGO:0051142 positive regulation of NK T cell proliferation IEA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031904 endosome lumen TAS
 cellular_componentGO:0043514 interleukin-12 complex IEA
 cellular_componentGO:0070743 interleukin-23 complex IDA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005126 cytokine receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042164 interleukin-12 alpha subunit binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0045519 interleukin-23 receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-12 signaling
Interleukin-23 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Akap10Gt(RRC139)Byg/Akap10+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il12btm2Lky/Il12btm2Lky
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S4/SvJae * BALB/c * C57BL/6J)

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Il12btm1Jm/Il12btm1Jm,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tcrdtm1Mom/Tcrdtm1Mom,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: C3tm1Crr/C3tm1Crr,Fcer1gtm1Rav/Fcer1gtm1Rav,Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il12btm1Jm/Il12btm1Jm,Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: involves: 129S1/SvImJ

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il12btm2Lky/Il12btm2Lky
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S4/SvJae * BALB/c * C57BL/6J)

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Akap10Gt(RRC139)Byg/Akap10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm,Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: involves: 129S1/SvImJ

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: 129S1/Sv-Il12btm1Jm

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm,Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

Allelic Composition: Il12btm1Jm/Il12btm1Jm
Genetic Background: involves: 129S1/SvImJ

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Akap10Gt(RRC139)Byg/Akap10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0030466 alveolar process atrophy "acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex / reaction
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex / reaction
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / reaction
 ENSMUSG00000025383 Il23a / Q9EQ14 / Interleukin-23 subunit alpha / Q9NPF7*  / reaction / complex
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000049093 Il23r / interleukin 23 receptor / Q5VWK5*  / complex






 

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