ENSMUSG00000000791


Mus musculus

Features
Gene ID: ENSMUSG00000000791
  
Biological name :Il12rb1
  
Synonyms : Il12rb1 / Interleukin-12 receptor subunit beta-1 / Q60837
  
Possible biological names infered from orthology : P42701
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 70808449
Gene end: 70821424
  
Corresponding Affymetrix probe sets: 10572497 (MoGene1.0st)   1418166_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148314
Ensembl peptide - ENSMUSP00000000808
Ensembl peptide - ENSMUSP00000148279
NCBI entrez gene - 16161     See in Manteia.
MGI - MGI:104579
RefSeq - XM_011242266
RefSeq - XM_006509558
RefSeq - XM_006509559
RefSeq - XM_006509560
RefSeq - XM_006509561
RefSeq - NM_008353
RefSeq - XM_006509557
RefSeq Peptide - NP_032379
swissprot - A0A1D5RLC9
swissprot - A0A1D5RL98
swissprot - Q60837
Ensembl - ENSMUSG00000000791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000035825Gallus gallus
 P42701ENSG00000096996Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host ISO
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response ISO
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0035722 interleukin-12-mediated signaling pathway IEA
 biological_processGO:0038155 interleukin-23-mediated signaling pathway IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation ISO
 biological_processGO:0071346 cellular response to interferon-gamma ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042022 interleukin-12 receptor complex ISO
 cellular_componentGO:0072536 interleukin-23 receptor complex IDA
 molecular_functionGO:0005143 interleukin-12 receptor binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016517 interleukin-12 receptor activity ISO
 molecular_functionGO:0019955 cytokine binding IPI
 molecular_functionGO:0042019 interleukin-23 binding ISO
 molecular_functionGO:0042020 interleukin-23 receptor activity ISO


Pathways (from Reactome)
Pathway description
Interleukin-12 signaling
Interleukin-23 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: involves: BALB/cJ

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex / reaction
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex / reaction
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / reaction / complex
 ENSMUSG00000025383 Il23a / Q9EQ14 / Interleukin-23 subunit alpha / Q9NPF7*  / complex
 ENSMUSG00000049093 Il23r / interleukin 23 receptor / Q5VWK5*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex






 

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