ENSMUSG00000027776


Mus musculus

Features
Gene ID: ENSMUSG00000027776
  
Biological name :Il12a
  
Synonyms : Il12a / interleukin 12a / P43431
  
Possible biological names infered from orthology : P29459
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E1
Gene start: 68690644
Gene end: 68698547
  
Corresponding Affymetrix probe sets: 10492540 (MoGene1.0st)   1425454_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029345
Ensembl peptide - ENSMUSP00000103446
NCBI entrez gene - 16159     See in Manteia.
MGI - MGI:96539
RefSeq - XM_006501044
RefSeq - NM_001159424
RefSeq - NM_008351
RefSeq Peptide - NP_001152896
RefSeq Peptide - NP_032377
swissprot - P43431
swissprot - Q549G3
swissprot - F8WI71
Ensembl - ENSMUSG00000027776
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL12AENSGALG00000009574Gallus gallus
 IL12AENSG00000168811Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004281  Interleukin-12 alpha
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IEA
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010224 response to UV-B IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032609 interferon-gamma production IGI
 biological_processGO:0032700 negative regulation of interleukin-17 production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032816 positive regulation of natural killer cell activation IEA
 biological_processGO:0032946 positive regulation of mononuclear cell proliferation IEA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035744 T-helper 1 cell cytokine production IGI
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042832 defense response to protozoan IGI
 biological_processGO:0045582 positive regulation of T cell differentiation IGI
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0051135 positive regulation of NK T cell activation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031904 endosome lumen TAS
 cellular_componentGO:0043514 interleukin-12 complex IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005143 interleukin-12 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042163 interleukin-12 beta subunit binding IEA
 molecular_functionGO:0045513 interleukin-27 binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-35 Signalling
Interleukin-12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il12btm1Jm/Il12btm1Jm,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: C3tm1Crr/C3tm1Crr,Fcer1gtm1Rav/Fcer1gtm1Rav,Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il12atm1Jm/Il12atm1Jm,Il12btm1Jm/Il12btm1Jm
Genetic Background: B6.129S1-Il12atm1Jm Il12btm1Jm

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Il12atm1Jm/Il12atm1Jm,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S6/SvEvTac

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: KitW-b/KitW-s
Genetic Background: involves: BRS * C57BL/St

Allelic Composition: Il12atm1Cab/Il12atm1Cab
Genetic Background: B6.129S4-Il12atm1Cab

 MP:0008618 decreased circulating interleukin-12 level "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: KitW-b/KitW-s
Genetic Background: involves: BRS * C57BL/St

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Raxey1/Raxey1
Genetic Background: ZRDCT/Ch-Raxey1

Allelic Composition: Il12atm1Cab/Il12atm1Cab
Genetic Background: B6.129S4-Il12atm1Cab

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex / reaction
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / complex
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex / reaction
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / complex
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex






 

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