ENSMUSG00000062939


Mus musculus

Features
Gene ID: ENSMUSG00000062939
  
Biological name :Stat4
  
Synonyms : signal transducer and activator of transcription 4 / Stat4
  
Possible biological names infered from orthology : Q14765
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.1
Gene start: 51987148
Gene end: 52107189
  
Corresponding Affymetrix probe sets: 10346168 (MoGene1.0st)   1448713_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027277
Ensembl peptide - ENSMUSP00000130713
NCBI entrez gene - 20849     See in Manteia.
MGI - MGI:103062
RefSeq - XM_006495816
RefSeq - NM_001308266
RefSeq - NM_011487
RefSeq - XM_006495814
RefSeq - XM_006495815
RefSeq Peptide - NP_001295195
RefSeq Peptide - NP_035617
swissprot - Q3V157
Ensembl - ENSMUSG00000062939
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat4ENSDARG00000028731Danio rerio
 STAT4ENSGALG00000033087Gallus gallus
 STAT4ENSG00000138378Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stat1 / signal transducer and activator of transcription 1 / P42224*ENSMUSG0000002610453
Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*ENSMUSG0000000404048
Stat2 / signal transducer and activator of transcription 2 / P52630*ENSMUSG0000004003337
P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*ENSMUSG0000002091930
P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*ENSMUSG0000000404329
Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*ENSMUSG0000000214725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR029839  Signal transducer and activator of transcription 4
 IPR035856  STAT4, SH2 domain
 IPR036535  STAT transcription factor, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-21 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: NOD.129S2-Stat4tm1Gru

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: NOD.129S2-Stat4tm1Gru

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002425 altered susceptibility to autoimmune disorder "a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rxrgtm2Ysa/Rxrgtm2Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

Allelic Composition: Stat4tm1Gru/Stat4tm1Gru,Tg(Ins2-NP)25-3Olds/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Stat4tm1Jni/Stat4tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: NOD.129S2-Stat4tm1Gru

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat4tm1Jni/Stat4tm1Jni,Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

Allelic Composition: Stat4tm1Gru/Stat4tm1Gru,Tg(Ins2-NP)25-3Olds/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: NOD.129S2-Stat4tm1Gru

Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: C.129S2-Stat4tm1Gru

Allelic Composition: Stat4tm1Jni/Stat4tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008600 decreased circulating interleukin-2 level "reduction in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: NOD.129S2-Stat4tm1Gru

Allelic Composition: Stat4tm1Gru/Stat4tm1Gru
Genetic Background: C.129S2-Stat4tm1Gru

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Stat4tm1Jni/Stat4tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Stat4tm1Jni/Stat4tm1Jni,Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

Allelic Composition: Stat4ity14/Stat4tm1Gru
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Tbx5tm1.1Jse/Tbx5+
Genetic Background: involves: Black Swiss

Allelic Composition: Stat4tm1Jni/Stat4tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex / reaction
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000049093 Il23r / interleukin 23 receptor / Q5VWK5*  / complex
 ENSMUSG00000030745 Il21r / Q9JHX3 / Interleukin-21 receptor / Q9HBE5*  / complex
 ENSMUSG00000027718 Il21 / Q9ES17 / Interleukin-21 / Q9HBE4*  / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex / reaction
 ENSMUSG00000025383 Il23a / Q9EQ14 / Interleukin-23 subunit alpha / Q9NPF7*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex






 

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