ENSMUSG00000027718


Mus musculus

Features
Gene ID: ENSMUSG00000027718
  
Biological name :Il21
  
Synonyms : Il21 / Interleukin-21 / Q9ES17
  
Possible biological names infered from orthology : Q9HBE4
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 37222759
Gene end: 37232636
  
Corresponding Affymetrix probe sets: 10497886 (MoGene1.0st)   1450334_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029273
Ensembl peptide - ENSMUSP00000124668
NCBI entrez gene - 60505     See in Manteia.
MGI - MGI:1890474
RefSeq - NM_001291041
RefSeq - NM_021782
RefSeq Peptide - NP_001277970
RefSeq Peptide - NP_068554
swissprot - Q9ES17
swissprot - Q5SUE2
swissprot - E9PX58
Ensembl - ENSMUSG00000027718
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL21ENSGALG00000011844Gallus gallus
 IL21ENSG00000138684Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR028151  Interleukin-21


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001783 B cell apoptotic process NAS
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0002729 positive regulation of natural killer cell cytokine production IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IDA
 biological_processGO:0032740 positive regulation of interleukin-17 production IEA
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IDA
 biological_processGO:0045579 positive regulation of B cell differentiation NAS
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0048469 cell maturation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005134 interleukin-2 receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-21 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndrg1tm1Hem/Ndrg1+
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fignfi/Fignfi
Genetic Background: mixed

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fignfi/Fignfi
Genetic Background: mixed

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008343 abnormal gamma-delta T cell morphology "any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSMUSG00000030745 Il21r / Q9JHX3 / Interleukin-21 receptor / Q9HBE5*  / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex






 

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