ENSMUSG00000031304


Mus musculus

Features
Gene ID: ENSMUSG00000031304
  
Biological name :Il2rg
  
Synonyms : Cytokine receptor common subunit gamma / Il2rg / P34902
  
Possible biological names infered from orthology : AL590764.2 / interleukin 2 receptor subunit gamma / P31785
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 101264378
Gene end: 101268255
  
Corresponding Affymetrix probe sets: 10606016 (MoGene1.0st)   1416295_a_at (Mouse Genome 430 2.0 Array)   1416296_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033664
Ensembl peptide - ENSMUSP00000123318
NCBI entrez gene - 16186     See in Manteia.
MGI - MGI:96551
RefSeq - XM_017318396
RefSeq - NM_001308535
RefSeq - NM_013563
RefSeq Peptide - NP_001295464
RefSeq Peptide - NP_038591
swissprot - P34902
swissprot - Q3UPA9
swissprot - B0QZX1
Ensembl - ENSMUSG00000031304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il2rgaENSDARG00000068858Danio rerio
 il2rgbENSDARG00000053702Danio rerio
 IL2RGENSGALG00000005638Gallus gallus
 AL590764.2ENSG00000285171Homo sapiens
 IL2RGENSG00000147168Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm20489 / IL2RG* / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*ENSMUSG0000009246369


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IMP
 biological_processGO:0045579 positive regulation of B cell differentiation IMP
 biological_processGO:0045621 positive regulation of lymphocyte differentiation IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019976 interleukin-2 binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0000494 abnormal cecum morphology "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1.2Gfk/Rb1+
Genetic Background: involves: 129T2/SvEms * C57BL/6 * SJL

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Il2rgtm1Krf/Il2rgtm1Krf
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)

Allelic Composition: Il2rgtm1Krf/Il2rgtm1Krf,Tg(Igh-Pim1)1Brn/0
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N)

Allelic Composition: Il2rgtm1Krf/Il2rgtm1Krf,Tg(BCL2/IGH)1Tjd/0
Genetic Background: either: (involves: 129P2/OlaHsd * C3H/He * C57BL/6) or (involves: 129P2/OlaHsd * C3H/He * C57BL/6 * FVB/N)

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * BALB/cAnNTac

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Il2rgtm1Wjl/Y,Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kittm1.1Bsm/Kittm1.1Bsm
Genetic Background: B6.129S1-Kittm1.1Bsm

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: B6;129S4-Jak3tm1Ljb/J

 MP:0002378 abnormal gut-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rb1tm1.2Gfk/Rb1+
Genetic Background: involves: 129T2/SvEms * C57BL/6 * SJL

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Il2rgtm1.1Flv/Y,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1.2Gfk/Rb1+
Genetic Background: involves: 129T2/SvEms * C57BL/6 * SJL

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002464 abnormal basophil physiology "abnormal function of the leukocyte that contains granules that stain with basic dyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0002879 increased sensitivity to X-ray irradiation "increased incidence of cell death following high levels of X-ray irradiation" [RGD:Rat Genome Database submission]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0004503 decreased incidence of ionizing radiation-induced tumors "lower than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il2ratm1Dw/Il2ratm1Dw,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2ratm1Dw Faslpr Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Cd47tm1Fpl/Cd47tm1Fpl,Il2rgtm1Cgn/Y
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0005046 failure of spleen white pulp formation "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

Allelic Composition: Il2rgtm1.1Flv/Y,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Il2rgtm1.1Flv/Il2rgtm1.1Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac

Allelic Composition: Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0005673 decreased susceptibility to graft versus host disease "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Cd47tm1Fpl/Cd47tm1Fpl,Il2rgtm1Cgn/Y
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0,Tg(LCKprBCL2)36Sjk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008041 absent NK T cells "absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm2Cgn/Y,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0008046 absent NK cells "absence of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129-Rag2tm1Fwa Il2rgtm1Cgn

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0008047 absent uterine NK cells "absence of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Cgn/Y,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129-Rag2tm1Fwa Il2rgtm1Cgn

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Cgn/Y,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129-Rag2tm1Fwa Il2rgtm1Cgn

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Cd47tm1Fpl/Cd47tm1Fpl,Il2rgtm1Cgn/Y
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Cd47tm1Fpl/Cd47tm1Fpl,Il2rgtm1Cgn/Y
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il2rgtm1.1Asin/Il2rgtm1Wjl,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: B6;129S4-Jak3tm1Ljb/J

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0008348 absent gamma-delta T cells "absence of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008352 absent gamma-delta intraepithelial T cell "absence of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008356 abnormal gamma-delta T cell differentiation "atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0008399 abnormal alpha-beta intraepithelial T cell morphology "any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0008464 absent peripheral lymph nodes "absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Cd47tm1Fpl/Cd47tm1Fpl,Il2rgtm1Cgn/Y
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Il2rgtm1Sug/Y
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl
Genetic Background: B6.129S4-Il2rgtm1Wjl/J

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0009020 prolonged metestrus "increase in the length of the metestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0010250 absent thymus cortex "lacking the outer part of the thymus lobule which surrounds the medulla and is normally composed of closely packed lymphocytes" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0010776 abnormal placenta metrial gland "any structural anomaly in the group of granular epithelial cells in the uterine muscle beneath the placenta that develops during pregnancy in rodents and some other species, but not in primates" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0012529 abnormal decidua basalis morphology "any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta" [MGI:anna]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0013587 absent thymus medulla "lacking the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

 MP:0013592 small thymus cortex "decreased size of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" [ISBN:0-683-40008-8, MGI:Anna]
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Allelic Composition: Il2rgtm1Wjl/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0014130 thymus cysts "presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (Hassall) corpuscles and epithelial reticulum of the thymus; congenital cysts are unilocular, whereas acquired cysts are usually multilocular and result as a consequence of inflammatory processes" [http://www.pedsradiology.com/historyanswer.aspx?qid=408&fid=1, PMID:23050117]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / reaction / complex
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / reaction / complex
 ENSMUSG00000020279 Il9r / Q01114 / Interleukin-9 receptor / Q01113*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000021538 Il9 / P15247 / Interleukin-9 / P15248*  / reaction / complex
 ENSMUSG00000026770 Il2ra / P01590 / interleukin 2 receptor, alpha chain / P01589* / interleukin 2 receptor subunit alpha*  / reaction / complex
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / complex / reaction
 ENSMUSG00000023206 Il15ra / Q60819 / Interleukin-15 receptor subunit alpha Soluble interleukin-15 receptor subunit alpha / Q13261* / interleukin 15 receptor subunit alpha*  / complex
 ENSMUSG00000068227 Il2rb / P16297 / Interleukin-2 receptor subunit beta / P14784*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / reaction / complex
 ENSMUSG00000031712 Il15 / P48346 / Interleukin-15 / P40933*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex
 ENSMUSG00000040329 Il7 / P10168 / Interleukin-7 / P13232*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSMUSG00000027720 Il2 / P04351 / Interleukin-2 / P60568*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000030745 Il21r / Q9JHX3 / Interleukin-21 receptor / Q9HBE5*  / complex
 ENSMUSG00000027718 Il21 / Q9ES17 / Interleukin-21 / Q9HBE4*  / complex
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / complex / reaction






 

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