ENSMUSG00000068227


Mus musculus

Features
Gene ID: ENSMUSG00000068227
  
Biological name :Il2rb
  
Synonyms : Il2rb / Interleukin-2 receptor subunit beta / P16297
  
Possible biological names infered from orthology : P14784
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 78479256
Gene end: 78495271
  
Corresponding Affymetrix probe sets: 10430344 (MoGene1.0st)   1417546_at (Mouse Genome 430 2.0 Array)   1443937_at (Mouse Genome 430 2.0 Array)   1448759_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086820
Ensembl peptide - ENSMUSP00000127006
NCBI entrez gene - 16185     See in Manteia.
MGI - MGI:96550
RefSeq - XM_006520481
RefSeq - NM_008368
RefSeq - XM_006520479
RefSeq - XM_006520480
RefSeq - XM_006520477
RefSeq - XM_006520478
RefSeq Peptide - NP_032394
swissprot - P16297
Ensembl - ENSMUSG00000068227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il2rbENSDARG00000075720Danio rerio
 IL2RBENSGALG00000012472Gallus gallus
 IL2RBENSG00000100385Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway ISO
 biological_processGO:0038110 interleukin-2-mediated signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004911 interleukin-2 receptor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019976 interleukin-2 binding IPI


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
Interleukin-15 signaling
Interleukin-2 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000653 abnormal sex gland morphology "anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004827 increased susceptibility to autoimmune hemolytic anemia "greater likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

 MP:0005002 abnormal T cell clonal deletion "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: D2.129-Il2rbtm1Mak

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: B6.129-Il2rbtm1Mak

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129 * 129S/SvEv

 MP:0008047 absent uterine NK cells "absence of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008180 abnormal marginal zone B cell morphology "any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rbtm1Mak/Il2rbtm1Mak
Genetic Background: C.129-Il2rbtm1Mak

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008247 abnormal mononuclear leukocyte morphology "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009097 absent endometrial glands "absence of the simple or branched tubular uterine glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000026770 Il2ra / P01590 / interleukin 2 receptor, alpha chain / P01589* / interleukin 2 receptor subunit alpha*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000027720 Il2 / P04351 / Interleukin-2 / P60568*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000031712 Il15 / P48346 / Interleukin-15 / P40933*  / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000023206 Il15ra / Q60819 / Interleukin-15 receptor subunit alpha Soluble interleukin-15 receptor subunit alpha / Q13261* / interleukin 15 receptor subunit alpha*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction






 

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