ENSG00000100385


Homo sapiens

Features
Gene ID: ENSG00000100385
  
Biological name :IL2RB
  
Synonyms : IL2RB / interleukin 2 receptor subunit beta / P14784
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q12.3
Gene start: 37125838
Gene end: 37175054
  
Corresponding Affymetrix probe sets: 205291_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400416
Ensembl peptide - ENSP00000403731
Ensembl peptide - ENSP00000402685
Ensembl peptide - ENSP00000401020
Ensembl peptide - ENSP00000216223
NCBI entrez gene - 3560     See in Manteia.
OMIM - 146710
RefSeq - NM_001346223
RefSeq - NM_000878
RefSeq - NM_001346222
RefSeq Peptide - NP_000869
RefSeq Peptide - NP_001333151
RefSeq Peptide - NP_001333152
swissprot - P14784
swissprot - B0QYC1
swissprot - B0QYC0
swissprot - H7C1H9
swissprot - B0QYC2
Ensembl - ENSG00000100385
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il2rbENSDARG00000075720Danio rerio
 IL2RBENSGALG00000012472Gallus gallus
 Il2rbENSMUSG00000068227Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0035723 interleukin-15-mediated signaling pathway TAS
 biological_processGO:0038110 interleukin-2-mediated signaling pathway TAS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004911 interleukin-2 receptor activity IDA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019976 interleukin-2 binding IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
Interleukin-15 signaling
Interleukin-2 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000689 Dental malocclusion "Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns." [HPO:curators]
Show

 HP:0001094 Iridocyclitis 
Show

 HP:0001373 Joint dislocation "Displacement or malalignment of joints." [HPO:curators]
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 HP:0001376 Decreased mobility of joints 
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 HP:0001386 Joint swelling 
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 HP:0002186 Apraxia "A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements." [HPO:curators]
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 HP:0002829 Arthralgia 
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 HP:0003493 Antinuclear antibody positive 
Show

 HP:0003565 Elevated erythrocyte sedimentation rate 
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 HP:0005681 Rheumatoid arthritis, juvenile 
Show

 HP:0005764 Polyarticular arthritis 
Show

 HP:0011227 Elevated C-reactive protein level "An abnormal elevation of the C-reactive protein level in serum." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000134460 IL2RA / P01589 / interleukin 2 receptor subunit alpha  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000109471 IL2 / P60568 / interleukin 2  / complex / reaction
 ENSG00000164136 IL15 / P40933 / interleukin 15  / complex
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / reaction / complex
 ENSG00000134470 IL15RA / Q13261 / interleukin 15 receptor subunit alpha  / complex
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / reaction / complex






 

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