ENSG00000164136


Homo sapiens

Features
Gene ID: ENSG00000164136
  
Biological name :IL15
  
Synonyms : IL15 / interleukin 15 / P40933
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.21
Gene start: 141636599
Gene end: 141733987
  
Corresponding Affymetrix probe sets: 205992_s_at (Human Genome U133 Plus 2.0 Array)   217371_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435462
Ensembl peptide - ENSP00000436914
Ensembl peptide - ENSP00000296545
Ensembl peptide - ENSP00000323505
Ensembl peptide - ENSP00000377714
Ensembl peptide - ENSP00000422271
NCBI entrez gene - 3600     See in Manteia.
OMIM - 600554
RefSeq - NM_000585
RefSeq - NM_172175
RefSeq Peptide - NP_000576
RefSeq Peptide - NP_751915
swissprot - P40933
Ensembl - ENSG00000164136
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL15ENSGALG00000009870Gallus gallus
 Il15ENSMUSG00000031712Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003443  Interleukin-15/Interleukin-21 family
 IPR009079  Four-helical cytokine-like, core
 IPR020439  Interleukin-15
 IPR020466  Interleukin-15, mammal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IEA
 biological_processGO:0001866 NK T cell proliferation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014732 skeletal muscle atrophy IEA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032740 positive regulation of interleukin-17 production IDA
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IEA
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IEA
 biological_processGO:0034105 positive regulation of tissue remodeling IC
 biological_processGO:0035723 interleukin-15-mediated signaling pathway TAS
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0045062 extrathymic T cell selection IEA
 biological_processGO:0045580 regulation of T cell differentiation IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048535 lymph node development IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050691 regulation of defense response to virus by host IEA
 biological_processGO:0050729 positive regulation of inflammatory response IC
 biological_processGO:0050778 positive regulation of immune response IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:1904100 positive regulation of protein O-linked glycosylation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-15 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134470 IL15RA / Q13261 / interleukin 15 receptor subunit alpha  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex
 ENSG00000100385 IL2RB / P14784 / interleukin 2 receptor subunit beta  / complex
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / complex
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / complex






 

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