ENSG00000109471


Homo sapiens

Features
Gene ID: ENSG00000109471
  
Biological name :IL2
  
Synonyms : IL2 / interleukin 2 / P60568
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q27
Gene start: 122451470
Gene end: 122456725
  
Corresponding Affymetrix probe sets: 207849_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000226730
NCBI entrez gene - 3558     See in Manteia.
OMIM - 147680
RefSeq - NM_000586
RefSeq Peptide - NP_000577
swissprot - P60568
swissprot - Q0GK43
Ensembl - ENSG00000109471
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il2ENSMUSG00000027720Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000779  Interleukin-2
 IPR009079  Four-helical cytokine-like, core
 IPR030477  Interleukin-2, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002366 leukocyte activation involved in immune response IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002903 negative regulation of B cell apoptotic process IDA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030101 natural killer cell activation TAS
 biological_processGO:0030217 T cell differentiation TAS
 biological_processGO:0030307 positive regulation of cell growth TAS
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032740 positive regulation of interleukin-17 production IDA
 biological_processGO:0034105 positive regulation of tissue remodeling IC
 biological_processGO:0038110 interleukin-2-mediated signaling pathway TAS
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0045589 regulation of regulatory T cell differentiation TAS
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IEA
 biological_processGO:0045822 negative regulation of heart contraction IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046013 regulation of T cell homeostatic proliferation IEA
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IEA
 biological_processGO:0050672 negative regulation of lymphocyte proliferation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IC
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:2000320 negative regulation of T-helper 17 cell differentiation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005134 interleukin-2 receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0019209 kinase activator activity TAS
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0031851 kappa-type opioid receptor binding IEA
 molecular_functionGO:0043208 glycosphingolipid binding IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Interleukin-2 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100385 IL2RB / P14784 / interleukin 2 receptor subunit beta  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000134460 IL2RA / P01589 / interleukin 2 receptor subunit alpha  / reaction / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / complex / reaction
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / reaction / complex






 

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