ENSMUSG00000023206


Mus musculus

Features
Gene ID: ENSMUSG00000023206
  
Biological name :Il15ra
  
Synonyms : Il15ra / Interleukin-15 receptor subunit alpha Soluble interleukin-15 receptor subunit alpha / Q60819
  
Possible biological names infered from orthology : interleukin 15 receptor subunit alpha / Q13261
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A1
Gene start: 11705290
Gene end: 11734317
  
Corresponding Affymetrix probe sets: 10469289 (MoGene1.0st)   1422397_a_at (Mouse Genome 430 2.0 Array)   1448681_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132058
Ensembl peptide - ENSMUSP00000131473
Ensembl peptide - ENSMUSP00000132731
Ensembl peptide - ENSMUSP00000077878
Ensembl peptide - ENSMUSP00000110480
Ensembl peptide - ENSMUSP00000110481
Ensembl peptide - ENSMUSP00000110482
Ensembl peptide - ENSMUSP00000110483
Ensembl peptide - ENSMUSP00000120539
Ensembl peptide - ENSMUSP00000126364
Ensembl peptide - ENSMUSP00000130792
NCBI entrez gene - 16169     See in Manteia.
MGI - MGI:104644
RefSeq - XM_017315695
RefSeq - NM_001271498
RefSeq - NM_001271499
RefSeq - NM_001271500
RefSeq - NM_001271501
RefSeq - NM_008358
RefSeq - NM_133836
RefSeq - XM_006497358
RefSeq - XM_006497359
RefSeq - XM_006497360
RefSeq - XM_006497362
RefSeq - XM_006497364
RefSeq - XM_011238959
RefSeq - NM_001271497
RefSeq Peptide - NP_001258430
RefSeq Peptide - NP_001258426
RefSeq Peptide - NP_001258427
RefSeq Peptide - NP_001258428
RefSeq Peptide - NP_001258429
RefSeq Peptide - NP_032384
RefSeq Peptide - NP_598597
swissprot - Q810T6
swissprot - Q501M1
swissprot - Q60819
swissprot - E9QA82
swissprot - A2AP38
Ensembl - ENSMUSG00000023206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL15RAENSG00000134470Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031965 nuclear membrane IEA


Pathways (from Reactome)
Pathway description
Interleukin-15 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/0,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6J * NMRI

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Dscamdel17/Dscamdel17
Genetic Background: B6.CBy-Dscamdel17/RwbJ

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6J * NMRI

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6J * NMRI

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl,Tg(TcrAND)53Hed/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0006412 abnormal T cell apoptosis "change in the timing or the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/0,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/0,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il15ratm1Wjl/Il15ratm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/0,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008363 decreased CD8-positive, gamma-delta intraepithelial T cell number "reduced number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6J * NMRI

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1.1Nsl/Il15ratm1.1Nsl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000031712 Il15 / P48346 / Interleukin-15 / P40933*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000068227 Il2rb / P16297 / Interleukin-2 receptor subunit beta / P14784*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr