ENSMUSG00000059923


Mus musculus

Features
Gene ID: ENSMUSG00000059923
  
Biological name :Grb2
  
Synonyms : Grb2 / Growth factor receptor-bound protein 2 / Q60631
  
Possible biological names infered from orthology : P62993
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 115644045
Gene end: 115708597
  
Corresponding Affymetrix probe sets: 10392990 (MoGene1.0st)   1418508_a_at (Mouse Genome 430 2.0 Array)   1449111_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102108
Ensembl peptide - ENSMUSP00000117539
Ensembl peptide - ENSMUSP00000021090
Ensembl peptide - ENSMUSP00000102104
Ensembl peptide - ENSMUSP00000102106
NCBI entrez gene - 14784     See in Manteia.
MGI - MGI:95805
RefSeq - NM_001313936
RefSeq - NM_001313937
RefSeq - NM_008163
RefSeq Peptide - NP_001300866
RefSeq Peptide - NP_032189
RefSeq Peptide - NP_001300865
swissprot - Q60631
swissprot - B1AT92
swissprot - Q3U5I5
swissprot - B1AT95
Ensembl - ENSMUSG00000059923
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grb2aENSDARG00000105276Danio rerio
 grb2bENSDARG00000038059Danio rerio
 GRB2ENSGALG00000008016Gallus gallus
 GRB2ENSG00000177885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grap / Q9CX99 / GRB2-related adapter protein / GRAPL* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2 related adaptor protein like*ENSMUSG0000000483757
Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*ENSMUSG0000004235149
Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*ENSMUSG0000003247525
Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*ENSMUSG0000006687723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR030219  Growth factor receptor-bound protein 2
 IPR035641  GRB2, N-terminal SH3 domain
 IPR035643  GRB2, C-terminal SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008286 insulin receptor signaling pathway ISO
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization IGI
 biological_processGO:0031623 receptor internalization ISO
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042770 signal transduction in response to DNA damage ISO
 biological_processGO:0043408 regulation of MAPK cascade IGI
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IMP
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0071479 cellular response to ionizing radiation ISO
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0008180 COP9 signalosome IDA
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0070436 Grb2-EGFR complex ISO
 molecular_functionGO:0001784 phosphotyrosine residue binding ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IDA
 molecular_functionGO:0005154 epidermal growth factor receptor binding ISO
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043560 insulin receptor substrate binding ISO
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0001074 abnormal vagus nerve morphology "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002031 adrenal tumor "tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(DO11.10)10Dlo/0,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129 * BALB/c * C3H * C57BL/6

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mecp2tm1Vnar/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0004868 endometrial carcinoma "malignant neoplasm arising from the endometrial tissue" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(DO11.10)10Dlo/0,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129 * BALB/c * C3H * C57BL/6

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc10tm1Emca/Hoxc10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Grb2tm1.1Hua/Grb2tm1.1Hua,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0008194 abnormal memory B cell physiology "abnormal function of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Xisttm2.1Jae/Xist+
Genetic Background: Not Specified

Allelic Composition: Grb2tm1Paw/Grb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / complex / reaction
 ENSMUSG00000001036 Epn2 / Q8CHU3 / Epsin-2 / O95208*  / complex / reaction
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex / reaction
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSMUSG00000020312 Shc2 / Q8BMC3 / SHC (Src homology 2 domain containing) transforming protein 2 / P98077* / SHC adaptor protein 2*  / complex / reaction
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / complex / reaction
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / reaction / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / complex / reaction
 ENSMUSG00000022901 Cd86 / P42082 / T-lymphocyte activation antigen CD86 / P42081* / CD86 molecule*  / complex / reaction
 ENSMUSG00000022114 Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex / reaction
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000009630 P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / P62714* / protein phosphatase 2 catalytic subunit beta*  / reaction / complex
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / reaction / complex
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction / complex
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / reaction / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / reaction / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex / reaction
 ENSMUSG00000055447 Cd47 / Q61735 / Leukocyte surface antigen CD47 / Q08722* / CD47 molecule*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000020349 P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P67775* / protein phosphatase 2 catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / complex / reaction
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex / reaction
 ENSMUSG00000026012 Cd28 / P31041 / T-cell-specific surface glycoprotein CD28 / P10747* / CD28 molecule*  / complex / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSMUSG00000023266 Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*  / reaction / complex
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction
 ENSMUSG00000068227 Il2rb / P16297 / Interleukin-2 receptor subunit beta / P14784*  / complex
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / complex / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / complex / reaction
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / reaction / complex
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / complex / reaction
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / reaction / complex
 ENSMUSG00000075122 Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*  / reaction / complex
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000007564 Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*  / reaction / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / reaction / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / complex / reaction
 ENSMUSG00000030724 Cd19 / P25918 / Mus musculus CD19 antigen (Cd19), transcript variant 2, mRNA. / P15391* / CD19 molecule*  / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / reaction / complex
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / complex / reaction
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction / complex
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex / reaction
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / complex / reaction
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / reaction / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000022309 Angpt1 / O08538 / Angiopoietin-1 / Q15389*  / reaction / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction / complex
 ENSMUSG00000031712 Il15 / P48346 / Interleukin-15 / P40933*  / complex
 ENSMUSG00000027303 Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000052013 Btla / B and T lymphocyte associated / Q7Z6A9*  / reaction / complex
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction / complex
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / reaction / complex
 ENSMUSG00000040855 Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*  / complex
 ENSMUSG00000042817 Flt3 / fms related tyrosine kinase 3 / P36888*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex / reaction
 ENSMUSG00000110206 Flt3l / P49772 / Fms-related tyrosine kinase 3 ligand / FLT3LG* / P49771*  / complex
 ENSMUSG00000044147 Arf6 / P62331 / ADP-ribosylation factor 6 / P62330*  / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex / reaction
 ENSMUSG00000023206 Il15ra / Q60819 / Interleukin-15 receptor subunit alpha Soluble interleukin-15 receptor subunit alpha / Q13261* / interleukin 15 receptor subunit alpha*  / complex
 ENSMUSG00000020395 Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*  / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000020740 Gga3 / Q8BMI3 / ADP-ribosylation factor-binding protein GGA3 / Q9NZ52* / golgi associated, gamma adaptin ear containing, ARF binding protein 3*  / complex
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / complex / reaction
 ENSMUSG00000021448 Shc3 / Q61120 / src homology 2 domain-containing transforming protein C3 / Q92529* / SHC adaptor protein 3*  / complex / reaction
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction / complex
 ENSMUSG00000040751 Lat2 / Q9JHL0 / Linker for activation of T-cells family member 2 / Q9GZY6*  / complex / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSMUSG00000028552 Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / reaction / complex
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction / complex
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / complex
 ENSMUSG00000035203 Epn1 / Q80VP1 / Epsin-1 / Q9Y6I3*  / reaction / complex
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / complex / reaction
 ENSMUSG00000055254 Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSMUSG00000055371 Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr