ENSMUSG00000018916


Mus musculus

Features
Gene ID: ENSMUSG00000018916
  
Biological name :Csf2
  
Synonyms : Csf2 / Granulocyte-macrophage colony-stimulating factor / P01587
  
Possible biological names infered from orthology : colony stimulating factor 2 / P04141
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 54247271
Gene end: 54249667
  
Corresponding Affymetrix probe sets: 10385912 (MoGene1.0st)   1427429_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019060
NCBI entrez gene - 12981     See in Manteia.
MGI - MGI:1339752
RefSeq - NM_009969
RefSeq Peptide - NP_034099
swissprot - P01587
swissprot - Q5SX78
Ensembl - ENSMUSG00000018916
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CSF2ENSG00000164400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000773  Granulocyte-macrophage colony-stimulating factor
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0030223 neutrophil differentiation IDA
 biological_processGO:0030224 monocyte differentiation IDA
 biological_processGO:0032747 positive regulation of interleukin-23 production IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045918 negative regulation of cytolysis IEA
 biological_processGO:0071803 positive regulation of podosome assembly IEA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 biological_processGO:0097028 dendritic cell differentiation IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005129 granulocyte macrophage colony-stimulating factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
Show

Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0002224 abnormal spleen size "deviation from the normal spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003211 abnormal aorta elastic fiber morphology "malformation of a slender connective tissue fiber in aortic tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

 MP:0003356 impaired lutenization "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:57854, J:43075]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003579 ovarian carcinoma 
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0005040 abnormal MHC II cell surface expression on macrophages "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31326]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0008903 abnormal mesenteric fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mesentery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0009020 prolonged metestrus "increase in the length of the metestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0009298 increased mesenteric fat pad weight 
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0010998 pulmonary alveolar proteinosis "abnormal intra-alveolar accumulation of an amorphous, largely cell-free, surfactant-like lipoproteinaceous material that is not easily cleared from the lungs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0011640 abnormal aorta collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

 MP:0012098 increased spongiotrophoblast size "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0012109 decreased trophoblast glycogen cell number "reduced number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [MGI:csmith]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
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Allelic Composition: ApcMin/Apctm1.1Klne
Genetic Background: B6.Cg-ApcMin/Apctm1.1Klne

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000026288 Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*  / reaction / complex
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000032737 Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / complex / reaction
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / reaction / complex






 

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