ENSMUSG00000004266


Mus musculus

Features
Gene ID: ENSMUSG00000004266
  
Biological name :Ptpn6
  
Synonyms : P29351 / protein tyrosine phosphatase, non-receptor type 6 / Ptpn6
  
Possible biological names infered from orthology : P29350
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124720707
Gene end: 124738714
  
Corresponding Affymetrix probe sets: 10547769 (MoGene1.0st)   1456694_x_at (Mouse Genome 430 2.0 Array)   1460188_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134638
Ensembl peptide - ENSMUSP00000133429
Ensembl peptide - ENSMUSP00000129124
Ensembl peptide - ENSMUSP00000108103
Ensembl peptide - ENSMUSP00000133747
Ensembl peptide - ENSMUSP00000004377
Ensembl peptide - ENSMUSP00000133991
Ensembl peptide - ENSMUSP00000134274
NCBI entrez gene - 15170     See in Manteia.
MGI - MGI:96055
RefSeq - NM_013545
RefSeq - NM_001077705
RefSeq Peptide - NP_038573
RefSeq Peptide - NP_001071173
swissprot - Q3UCJ0
swissprot - G3UWU7
swissprot - G3UXM2
swissprot - G3UYY5
swissprot - G3UZU6
swissprot - P29351
Ensembl - ENSMUSG00000004266
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn6ENSDARG00000089043Danio rerio
 PTPN6ENSGALG00000014561Gallus gallus
 PTPN6ENSG00000111679Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*ENSMUSG0000004373355
Ptprn / protein tyrosine phosphatase, receptor type, N / Q16849*ENSMUSG0000002620423
P80560 / Ptprn2 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / Q92932* / protein tyrosine phosphatase, receptor type N2*ENSMUSG0000005655322
Ptprr / Q62132 / protein tyrosine phosphatase, receptor type, R / Q15256*ENSMUSG0000002015120
Ptpn5 / P54830 / Tyrosine-protein phosphatase non-receptor type 5 / P54829* / protein tyrosine phosphatase, non-receptor type 5*ENSMUSG0000003085420
Ptpn7 / Q8BUM3 / Mus musculus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant 2, mRNA. / P35236* / protein tyrosine phosphatase, non-receptor type 7*ENSMUSG0000003150618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000980  SH2 domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012152  Protein-tyrosine phosphatase, non-receptor type-6, -11
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation ISO
 biological_processGO:0030220 platelet formation IGI
 biological_processGO:0033277 abortive mitotic cell cycle IMP
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0043409 negative regulation of MAPK cascade IMP
 biological_processGO:0045577 regulation of B cell differentiation IMP
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:0050859 negative regulation of B cell receptor signaling pathway IGI
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IGI
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070527 platelet aggregation IMP
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042105 alpha-beta T cell receptor complex IDA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005001 transmembrane receptor protein tyrosine phosphatase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0042169 SH2 domain binding IDA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI
 molecular_functionGO:0140031 phosphorylation-dependent protein binding ISO


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Regulation of KIT signaling
Costimulation by the CD28 family
PD-1 signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Enpp1m1Amgn/Enpp1m1Amgn
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

Allelic Composition: Ptpn6me-2J/Ptpn6me-2J
Genetic Background: Not Specified

 MP:0000549 absent limbs "missing extremities" [J:51966, J:50768]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3H/HeN * C57BL/6J * NFS

Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0000578 ulcerated paws "inflammatory, often suppurating lesions on the paws; often become necrotic" [J:17194]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr,Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ptpn6m1Btlr Ticam1Lps2

Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr,Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr Ptpn6m1Btlr

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: either: (involves: C3H * C57BL/6J) or (involves: C57BL/6J * C57BL/6N)

 MP:0001189 absent skin pigmentation "lack of pigmentation of the skin" [J:53370]
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Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3H/HeN * C57BL/6J * NFS

Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Enpp1m1Amgn/Enpp1m1Amgn
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptpn6me-2J/Ptpn6me-2J
Genetic Background: Not Specified

Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: either: (involves: C3H * C57BL/6J) or (involves: C57BL/6J * C57BL/6N)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3H/HeN * C57BL/6J * NFS

Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: either: (involves: C3H * C57BL/6J) or (involves: C57BL/6J * C57BL/6N)

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn6me-2J/Ptpn6me-2J
Genetic Background: Not Specified

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myctm2Fwa/Myc+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax5m1Anu/Pax5m1Anu
Genetic Background: C57BL/6JAnu-Pax5m1Anu

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: either: (involves: C3H * C57BL/6J) or (involves: C57BL/6J * C57BL/6N)

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: either: (involves: C3H * C57BL/6J) or (involves: C57BL/6J * C57BL/6N)

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn6me-2J/Ptpn6me-2J
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3H/HeN * C57BL/6J * NFS

Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptpn6me-2J/Ptpn6me-2J
Genetic Background: Not Specified

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3H/HeN * C57BL/6J * NFS

Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

 MP:0003201 extremity edema "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: either: (involves: C3H * C57BL/6J) or (involves: C57BL/6J * C57BL/6N)

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3H/HeN * C57BL/6J * NFS

Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Enpp1m1Amgn/Enpp1m1Amgn
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0004944 abnormal B cell negative selection "any anomaly in the process through which B cells which react strongly with self-antigens are eliminated, usually through anergy or deletion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd22tm1Eac/Cd22+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic Background: C57BL/6J-Ptpn6m3Btlr

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax3m2Btlr/Pax3m2Btlr
Genetic Background: C57BL/6J-Pax3M2Btlr

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust,Ptpn6me-v/Ptpn6me-v
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic Background: C57BL/6J-Ptpn6m3Btlr

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic Background: C57BL/6J-Ptpn6m3Btlr

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic Background: C57BL/6J-Ptpn6m3Btlr

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Ard/Lyn+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Ard/Lyn+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd22tm1Eac/Cd22+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic Background: C57BL/6J-Ptpn6m3Btlr

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

Allelic Composition: Ptpn6me-v/Ptpn6me-v
Genetic Background: C57BL/6J-Ptpn6me-v

Allelic Composition: Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic Background: C57BL/6J-Ptpn6m3Btlr

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic Background: C57BL/6J-Ptpn6m3Btlr

Allelic Composition: Ptpn6m3Btlr/Ptpn6+
Genetic Background: C57BL/6J-Ptpn6m3Btlr

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Enpp1m1Amgn/Enpp1m1Amgn
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3H/HeN * C57BL/6J * NFS

Allelic Composition: Btkxid/?,Ptpn6me/Ptpn6me
Genetic Background: involves: C57BL/6J * CBA/N * NFS

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic Background: C57BL/6J-Ptpn6m1Btlr/Mmucd

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Enpp1m1Amgn/Enpp1m1Amgn
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0010214 abnormal circulating serum amyloid protein level "deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [MESH:D12.776.049.790, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6me-B2/Ptpn6me-B2
Genetic Background: involves: BALB/c

 MP:0010899 abnormal pulmonary alveolar system morphology 
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0020448 increased microglial cell activation "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
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Allelic Composition: Ptpn6me/Ptpn6me
Genetic Background: involves: C3HeB/FeJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / complex / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction
 ENSMUSG00000003379 Cd79a / P11911 / B-cell antigen receptor complex-associated protein alpha chain / P11912* / CD79a molecule*  / reaction / complex
 ENSMUSG00000040592 Cd79b / P15530 / B-cell antigen receptor complex-associated protein beta chain / P40259* / CD79b molecule*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction
 ENSMUSG00000073414 D7PDD4 / Mpig6b / Megakaryocyte and platelet inhibitory receptor G6b / O95866*  / complex / reaction
 ENSMUSG00000052013 Btla / B and T lymphocyte associated / Q7Z6A9*  / reaction / complex
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / reaction / complex
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / reaction
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / reaction
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / reaction
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / complex / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / reaction
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000016496 Cd274 / Q9EP73 / CD274 antigen / Q9NZQ7* / CD274 molecule*  / complex / reaction
 ENSMUSG00000026285 Pdcd1 / Q02242 / programmed cell death 1 / Q15116*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / reaction / complex
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / reaction / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / complex / reaction
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / reaction / complex
 ENSMUSG00000016498 Q9WUL5 / Pdcd1lg2 / programmed cell death 1 ligand 2 / Q9BQ51*  / complex / reaction
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / complex / reaction






 

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