ENSMUSG00000026204


Mus musculus

Features
Gene ID: ENSMUSG00000026204
  
Biological name :Ptprn
  
Synonyms : protein tyrosine phosphatase, receptor type, N / Ptprn
  
Possible biological names infered from orthology : Q16849
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C4
Gene start: 75247027
Gene end: 75264502
  
Corresponding Affymetrix probe sets: 10355813 (MoGene1.0st)   1416588_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027404
Ensembl peptide - ENSMUSP00000140168
Ensembl peptide - ENSMUSP00000140062
Ensembl peptide - ENSMUSP00000139925
NCBI entrez gene - 19275     See in Manteia.
MGI - MGI:102765
RefSeq - XM_006496444
RefSeq - XM_011238678
RefSeq - XM_011238677
RefSeq - XM_006496445
RefSeq - NM_001359281
RefSeq - NM_008985
RefSeq Peptide - NP_001346210
RefSeq Peptide - NP_033011
swissprot - A6MDD2
swissprot - A0A087WPU7
swissprot - A0A087WQ67
swissprot - A0A087WQF2
Ensembl - ENSMUSG00000026204
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprnaENSDARG00000058646Danio rerio
 ptprnbENSDARG00000077047Danio rerio
 PTPRNENSGALG00000033811Gallus gallus
 PTPRNENSG00000054356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P80560 / Ptprn2 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / Q92932* / protein tyrosine phosphatase, receptor type N2*ENSMUSG0000005655343
P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*ENSMUSG0000004373314
Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*ENSMUSG0000000426614
Ptprr / Q62132 / protein tyrosine phosphatase, receptor type, R / Q15256*ENSMUSG0000002015114
Ptpn5 / P54830 / Tyrosine-protein phosphatase non-receptor type 5 / P54829* / protein tyrosine phosphatase, non-receptor type 5*ENSMUSG0000003085412
Ptpn7 / Q8BUM3 / Mus musculus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant 2, mRNA. / P35236* / protein tyrosine phosphatase, non-receptor type 7*ENSMUSG0000003150610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR021613  Protein-tyrosine phosphatase receptor IA-2 ectodomain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029403  RESP18 domain
 IPR033522  Receptor-type tyrosine-protein phosphatase-like N/N2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:1904692 positive regulation of type B pancreatic cell proliferation IEA
 biological_processGO:1990502 dense core granule maturation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0030507 spectrin binding IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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