ENSG00000054356


Homo sapiens

Features
Gene ID: ENSG00000054356
  
Biological name :PTPRN
  
Synonyms : protein tyrosine phosphatase, receptor type N / PTPRN / Q16849
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q35
Gene start: 219289623
Gene end: 219309648
  
Corresponding Affymetrix probe sets: 204945_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392598
Ensembl peptide - ENSP00000475591
Ensembl peptide - ENSP00000408036
Ensembl peptide - ENSP00000397105
Ensembl peptide - ENSP00000396842
Ensembl peptide - ENSP00000396464
Ensembl peptide - ENSP00000395379
Ensembl peptide - ENSP00000295718
Ensembl peptide - ENSP00000386638
Ensembl peptide - ENSP00000388429
NCBI entrez gene - 5798     See in Manteia.
OMIM - 601773
RefSeq - XM_017004612
RefSeq - XM_017004611
RefSeq - XM_017004610
RefSeq - XM_017004609
RefSeq - XM_011511566
RefSeq - NM_001199763
RefSeq - NM_002846
RefSeq - NM_001199764
RefSeq Peptide - NP_001186692
RefSeq Peptide - NP_001186693
RefSeq Peptide - NP_002837
swissprot - C9JJL7
swissprot - Q16849
swissprot - U3KQ66
swissprot - H7C0U9
swissprot - A0A1B0GX26
swissprot - C9J392
swissprot - C9JR27
swissprot - C9JCQ0
Ensembl - ENSG00000054356
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprnaENSDARG00000058646Danio rerio
 ptprnbENSDARG00000077047Danio rerio
 PTPRNENSGALG00000033811Gallus gallus
 PtprnENSMUSG00000026204Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRN2 / Q92932 / protein tyrosine phosphatase, receptor type N2ENSG0000015509344
PTPRR / Q15256 / protein tyrosine phosphatase, receptor type RENSG0000015323315
PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11ENSG0000017929515
PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6ENSG0000011167914
PTPN5 / P54829 / protein tyrosine phosphatase, non-receptor type 5ENSG0000011078613
PTPN7 / P35236 / protein tyrosine phosphatase, non-receptor type 7ENSG0000014385111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR021613  Protein-tyrosine phosphatase receptor IA-2 ectodomain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029403  RESP18 domain
 IPR033522  Receptor-type tyrosine-protein phosphatase-like N/N2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IDA
 biological_processGO:0001553 luteinization ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030073 insulin secretion IGI
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035773 insulin secretion involved in cellular response to glucose stimulus ISS
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:1904692 positive regulation of type B pancreatic cell proliferation IDA
 biological_processGO:1990502 dense core granule maturation IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030141 secretory granule ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus ISS
 cellular_componentGO:0045202 synapse ISS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0030507 spectrin binding IPI
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IDA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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