ENSMUSG00000043733


Mus musculus

Features
Gene ID: ENSMUSG00000043733
  
Biological name :Ptpn11
  
Synonyms : P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11
  
Possible biological names infered from orthology : protein tyrosine phosphatase, non-receptor type 11 / Q06124
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 121130533
Gene end: 121191397
  
Corresponding Affymetrix probe sets: 10533285 (MoGene1.0st)   1421196_at (Mouse Genome 430 2.0 Array)   1427699_a_at (Mouse Genome 430 2.0 Array)   1451225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058757
Ensembl peptide - ENSMUSP00000098333
NCBI entrez gene - 19247     See in Manteia.
MGI - MGI:99511
RefSeq - NM_001109992
RefSeq - NM_011202
RefSeq Peptide - NP_001103462
RefSeq Peptide - NP_035332
swissprot - P35235
Ensembl - ENSMUSG00000043733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn11aENSDARG00000020334Danio rerio
 PTPN11ENSGALG00000004821Gallus gallus
 PTPN11ENSG00000179295Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*ENSMUSG0000000426655
Ptprn / protein tyrosine phosphatase, receptor type, N / Q16849*ENSMUSG0000002620424
P80560 / Ptprn2 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / Q92932* / protein tyrosine phosphatase, receptor type N2*ENSMUSG0000005655323
Ptprr / Q62132 / protein tyrosine phosphatase, receptor type, R / Q15256*ENSMUSG0000002015122
Ptpn5 / P54830 / Tyrosine-protein phosphatase non-receptor type 5 / P54829* / protein tyrosine phosphatase, non-receptor type 5*ENSMUSG0000003085422
Ptpn7 / Q8BUM3 / Mus musculus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant 2, mRNA. / P35236* / protein tyrosine phosphatase, non-receptor type 7*ENSMUSG0000003150619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000980  SH2 domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012152  Protein-tyrosine phosphatase, non-receptor type-6, -11
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IMP
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IGI
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IDA
 biological_processGO:0009967 positive regulation of signal transduction IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0021697 cerebellar cortex formation IMP
 biological_processGO:0030220 platelet formation IGI
 biological_processGO:0032528 microvillus organization IMP
 biological_processGO:0033277 abortive mitotic cell cycle IMP
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0035265 organ growth IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0036302 atrioventricular canal development IEA
 biological_processGO:0038127 ERBB signaling pathway IEA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042445 hormone metabolic process IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IGI
 biological_processGO:0046676 negative regulation of insulin secretion IMP
 biological_processGO:0046825 regulation of protein export from nucleus IMP
 biological_processGO:0046887 positive regulation of hormone secretion IMP
 biological_processGO:0046888 negative regulation of hormone secretion IMP
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IGI
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IMP
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048609 multicellular organismal reproductive process IMP
 biological_processGO:0048806 genitalia development IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0051463 negative regulation of cortisol secretion IMP
 biological_processGO:0060020 Bergmann glial cell differentiation IMP
 biological_processGO:0060125 negative regulation of growth hormone secretion IMP
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0061582 intestinal epithelial cell migration IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity ISO
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IPI
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
PI3K Cascade
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Spry regulation of FGF signaling
Signaling by SCF-KIT
GAB1 signalosome
Downstream signal transduction
Tie2 Signaling
Costimulation by the CD28 family
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin-20 family signaling
MET activates PTPN11
Regulation of RUNX1 Expression and Activity
Interferon alpha/beta signaling
Regulation of IFNA signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0000073 absent craniofacial bones "missing skeletal elements comprising the cranium and face" [J:35802]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra,Tcrb)HRCAll/0
Genetic Background: B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: B6.129S4-Ptpn11tm1Bgn

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm7Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nppctm1.1Fgr/Nppctm1.1Fgr,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns

 MP:0000447 flattened snout 
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm7Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001109 absent Schwann cell precursors "missing progenitors of cells that sheath the axons of the peripheral nervous system" [J:43515]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001221 epidermal atrophy "wasting of the epidermal layer of the skin" [J:65033]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001347 absent lacrimal glands "missing the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001684 abnormal axial mesoderm "malformed middle primary germ layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:51834]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001744 hypersecretion of cortisol 
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Stat3tm1Vpo/Stat3tm1Vpo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra,Tcrb)HRCAll/0
Genetic Background: B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll

Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra,Tcrb)HRCAll/0
Genetic Background: B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002251 abnormal nasopharynx morphology "structural anomaly of the section of the pharynx that lies above the soft palate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: B6.129X1-Col4a3tm1Dec

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Stat3tm1Vpo/Stat3tm1Vpo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0003441 increased glycerol level "higher than normal concentration of glycerol" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003820 increased left ventricle systolic pressure "increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0003869 ectopic cartilage "positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003958 heart valve hyperplasia "increased number of cells of the heart valves, leading to increased size or bulk" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:60214]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Hprttm1(CAG-cre)Mnn/Hprt+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0004049 acute promyelocytic leukemia "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0004075 reduced Schwann cell precursor number "fewer numbers than normal of the progenitors of cells that sheath the axons of the peripheral nervous system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0004134 abnormal chest morphology "malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Stat3tm1Vpo/Stat3tm1Vpo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0004965 inner cell mass degeneration 
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra,Tcrb)HRCAll/0
Genetic Background: B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006047 aortic valve insufficiency "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008384 absent nasal capsule "absence of the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009320 lymphoblastic lymphoma "diffuse lymphoma with supradiaphragmatic distribution and T lymphocytes having convoluted nuclei" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj

 MP:0009877 exostosis "a projection of bone, sometimes a benign tumor, that is capped by cartilage and arises from a bone that develops from cartilage" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009939 abnormal hippocampus neuron morphology 
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: B6.129S-Ptpn11tm6Bgn Emx1tm1(cre)Krj

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0010031 abnormal cranium size "deviation from the average range of cranium size compared to normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010336 increased acute lymphoblastic leukemia incidence 
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptpn11tm6Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010464 abnormal aortic arch and aortic arch branch attachment "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0010506 prolonged RR interval "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0010570 prolonged ST segment "increase in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0010589 common truncal valve "a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0010618 enlarged mitral valve "an increase in the total area occupied by the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: C.129S4-Ptpn11tm1Bgn

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: B6.129S4-Ptpn11tm1Bgn

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Ptpn11tm1Bgn/Ptpn11tm1Bgn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Hprttm1(CAG-cre)Mnn/Hprt+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011103 partial embryonic lethality at implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at the point of implantation (Mus: E4.5)" [MGI:csmith]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011904 abnormal Schwann cell physiology "any functional anomaly of the cells which form the insulating myelin sheaths of peripheral axons" [MESH:A08.637.800]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0012117 decreased trophectoderm cell proliferation 
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0012749 decreased cardiac neural crest cell number "reduction in the number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT), and contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

 MP:0012756 impaired cranial neural crest cell differentiation "abnormal or arrest of differentiation or patterning of the cranial neural crest cells" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor H2afvTg(Wnt1-cre)11Rth

 MP:0013002 decreased enteric neural crest cell number "a reduction in the number of neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut" [MGI:anna, PMID:17514199]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0013243 abnormal carbohydrate metabolism "any anomaly in the chemical reactions and pathways involving a carbohydrate, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0013331 abnormal lacrimal gland development "aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue" [MGI:Anna, PMID:22745308]
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Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0013697 decreased granulocyte monocyte progenitor cell number "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0020346 abnormal mycardial fiber calcium currents "any anomaly in the electrical currents produced by cardiac calcium ion channels, typically measured using whole-cell patch-clamp techniques" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0030020 decreased cardiac cell glucose uptake "reduced ability of the cells of the heart to take in glucose" [MGI:anna]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Ptpn11tm1Gsf/Ptpn11tm1Gsf,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0030034 depressed nasal bridge "posterior positioning of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose in relation to the overall facial profile for age; normally, it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [HP:0005280]
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Allelic Composition: Ptpn11tm4.2Bgn/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0030166 increased inner canthal distance "increased distance between the inner corners (medial canthi) of the eyes where the eyelids meet; may be present without or with ocular hypertelorism (where interpupillary distance is increased)" [HP:0000506, https://en.wikipedia.org/wiki/Telecanthus, PMID:19125427]
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Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Ptpn11tm7Bgn/Ptpn11tm7Bgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0030189 broad snout "increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030190 small snout "decreased size of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns H2afvTg(Wnt1-cre)11Rth

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / reaction / complex
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000016496 Cd274 / Q9EP73 / CD274 antigen / Q9NZQ7* / CD274 molecule*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000026011 Ctla4 / cytotoxic T-lymphocyte associated protein 4 / P16410*  / complex / reaction
 ENSMUSG00000022309 Angpt1 / O08538 / Angiopoietin-1 / Q15389*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / reaction / complex
 ENSMUSG00000026285 Pdcd1 / Q02242 / programmed cell death 1 / Q15116*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / reaction / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex / reaction
 ENSMUSG00000025746 Il6 / P08505 / interleukin 6 / P05231*  / reaction / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / reaction / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / reaction / complex
 ENSMUSG00000057722 Lepr / P48356 / Leptin receptor / P48357*  / reaction / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / complex / reaction
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / complex / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex / reaction
 ENSMUSG00000027947 Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / complex / reaction
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / reaction / complex
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / complex / reaction
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / reaction
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / complex / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction
 ENSMUSG00000027508 Pag1 / Q3U1F9 / phosphoprotein associated with glycosphingolipid microdomains 1 / Q9NWQ8* / phosphoprotein membrane anchor with glycosphingolipid microdomains 1*  / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000052013 Btla / B and T lymphocyte associated / Q7Z6A9*  / reaction / complex
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / complex / reaction
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / reaction
 ENSMUSG00000009630 P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / P62714* / protein phosphatase 2 catalytic subunit beta*  / reaction
 ENSMUSG00000020349 P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P67775* / protein phosphatase 2 catalytic subunit alpha*  / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / reaction
 ENSMUSG00000023266 Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*  / complex / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / reaction / complex
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction
 ENSMUSG00000073414 D7PDD4 / Mpig6b / Megakaryocyte and platelet inhibitory receptor G6b / O95866*  / reaction / complex
 ENSMUSG00000022114 Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*  / reaction
 ENSMUSG00000007564 Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*  / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / reaction
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / reaction
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / reaction / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex / reaction
 ENSMUSG00000059201 Lep / P41160 / Leptin / P41159*  / complex / reaction
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSMUSG00000022901 Cd86 / P42082 / T-lymphocyte activation antigen CD86 / P42081* / CD86 molecule*  / complex / reaction
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / reaction / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000074695 Il22 / Q9JJY9 / Interleukin-22 / Q9GZX6*  / complex / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction / complex
 ENSMUSG00000059921 Unc5c / O08747 / unc-5 netrin receptor C / O95185*  / complex / reaction
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / reaction / complex
 ENSMUSG00000037157 Q80XZ4 / Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q8N6P7*  / complex / reaction
 ENSMUSG00000075122 Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*  / reaction / complex
 ENSMUSG00000016498 Q9WUL5 / Pdcd1lg2 / programmed cell death 1 ligand 2 / Q9BQ51*  / complex / reaction
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / complex / reaction
 ENSMUSG00000090461 Q9JJY8 / Iltifb / Interleukin-22b / IL22* / Q9GZX6* / interleukin 22*  / reaction / complex






 

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