ENSMUSG00000021756


Mus musculus

Features
Gene ID: ENSMUSG00000021756
  
Biological name :Il6st
  
Synonyms : Il6st / Interleukin-6 receptor subunit beta / Q00560
  
Possible biological names infered from orthology : interleukin 6 signal transducer / P40189
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D2.2
Gene start: 112464070
Gene end: 112510086
  
Corresponding Affymetrix probe sets: 10407173 (MoGene1.0st)   1421239_at (Mouse Genome 430 2.0 Array)   1437303_at (Mouse Genome 430 2.0 Array)   1452843_at (Mouse Genome 430 2.0 Array)   1460295_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139311
Ensembl peptide - ENSMUSP00000064205
Ensembl peptide - ENSMUSP00000138820
Ensembl peptide - ENSMUSP00000138836
Ensembl peptide - ENSMUSP00000138915
Ensembl peptide - ENSMUSP00000138987
Ensembl peptide - ENSMUSP00000139016
Ensembl peptide - ENSMUSP00000139060
Ensembl peptide - ENSMUSP00000139180
Ensembl peptide - ENSMUSP00000139227
NCBI entrez gene - 16195     See in Manteia.
MGI - MGI:96560
RefSeq - NM_010560
RefSeq Peptide - NP_034690
swissprot - Q00560
swissprot - Q3TDT5
swissprot - V9GX00
swissprot - V9GX52
swissprot - V9GX73
swissprot - V9GXA2
swissprot - V9GXJ5
swissprot - V9GXT4
Ensembl - ENSMUSG00000021756
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il6stENSDARG00000104693Danio rerio
 IL6STENSGALG00000014716Gallus gallus
 IL6STENSG00000134352Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csf3r / P40223 / Granulocyte colony-stimulating factor receptor / Q99062* / colony stimulating factor 3 receptor*ENSMUSG0000002885922
Il31ra / Q8K5B1 / Interleukin-31 receptor subunit alpha / Q8NI17* / interleukin 31 receptor A*ENSMUSG0000005037719
P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*ENSMUSG0000001834119
Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*ENSMUSG0000005426318
Osmr / oncostatin M receptor / Q99650*ENSMUSG0000002214616


Protein motifs (from Interpro)
Interpro ID Name
 IPR003529  Long hematopoietin receptor, Gp130 family 2, conserved site
 IPR003961  Fibronectin type III
 IPR010457  Immunoglobulin C2-set-like, ligand-binding
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005977 glycogen metabolic process IMP
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008593 regulation of Notch signaling pathway IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway ISO
 biological_processGO:0034097 response to cytokine ISO
 biological_processGO:0038154 interleukin-11-mediated signaling pathway IEA
 biological_processGO:0038165 oncostatin-M-mediated signaling pathway ISO
 biological_processGO:0042102 positive regulation of T cell proliferation ISO
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0045669 positive regulation of osteoblast differentiation ISO
 biological_processGO:0048711 positive regulation of astrocyte differentiation IMP
 biological_processGO:0048861 leukemia inhibitory factor signaling pathway ISO
 biological_processGO:0070102 interleukin-6-mediated signaling pathway ISO
 biological_processGO:0070104 negative regulation of interleukin-6-mediated signaling pathway ISO
 biological_processGO:0070106 interleukin-27-mediated signaling pathway ISO
 biological_processGO:0070120 ciliary neurotrophic factor-mediated signaling pathway ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005896 interleukin-6 receptor complex ISO
 cellular_componentGO:0005900 oncostatin-M receptor complex ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0070110 ciliary neurotrophic factor receptor complex ISO
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004897 ciliary neurotrophic factor receptor activity ISO
 molecular_functionGO:0004915 interleukin-6 receptor activity ISO
 molecular_functionGO:0004921 interleukin-11 receptor activity IDA
 molecular_functionGO:0004923 leukemia inhibitory factor receptor activity ISO
 molecular_functionGO:0004924 oncostatin-M receptor activity ISO
 molecular_functionGO:0005127 ciliary neurotrophic factor receptor binding ISO
 molecular_functionGO:0005138 interleukin-6 receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019838 growth factor binding ISO
 molecular_functionGO:0019970 interleukin-11 binding IDA
 molecular_functionGO:0019981 interleukin-6 binding ISO


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
IL-6-type cytokine receptor ligand interactions
Interleukin-35 Signalling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tekt3tm1Zuk/Tekt3tm1Zuk,Tekt4tm1Zuk/Tekt4tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000168 abnormal bone marrow development "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm4Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000997 abnormal joint capsule morphology "anomalous structure of the sac that encloses the articulating ends of bones participating in a synovial joint " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gnastm1Lsw/Gnas+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il6sttm3Thir/Il6sttm3Thir
Genetic Background: Not Specified

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S1/Sv

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1.1Tes/Bdnftm1.1Tes
Genetic Background: B6.129X1-Bdnftm1.1Tes

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm3Thir/Il6sttm3Thir
Genetic Background: Not Specified

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm3Thir/Il6sttm3Thir
Genetic Background: Not Specified

 MP:0002224 abnormal spleen size "deviation from the normal spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gkn2tm1.1(KOMP)Vlcg/Gkn2tm1.1(KOMP)Vlcg,Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tg(RP11-H2112)9Trme/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6sttm3Thir/Il6sttm3Thir
Genetic Background: Not Specified

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: Not Specified

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: Not Specified

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002658 abnormal liver regeneration "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm4Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003282 gastric ulcer "a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003300 gastrointestinal ulcer "any lesion on the mucosal surface of the gastrointestinal tract, usually produced by the sloughing of inflammatory necrotic tissue" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003432 increased activity of parathyroid "increased function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003486 abnormal channel response intensity 
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003795 abnormal bone structure 
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Allelic Composition: Tekt3tm1Zuk/Tekt3tm1Zuk,Tekt4tm1Zuk/Tekt4tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004358 bowed tibia "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004361 bowed ulna "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004371 bowed femur "increased curvature of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004372 bowed fibula "increased curvature of the lateral and smaller bone of the lower limb" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004373 bowed humerus "increased curvature of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Il6sttm1Thir/Il6sttm1Thir
Genetic Background: involves: 129 * C57BL/6

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0005002 abnormal T cell clonal deletion "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tekt3tm1Zuk/Tekt3tm1Zuk,Tekt4tm1Zuk/Tekt4tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005211 increased thickness of gastric mucosa "greater than the normal depth or width of the epithelial layer of the stomach" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
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Allelic Composition: Ino80tm1.1Schg/Ino80+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Adv/Trp53+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008069 abnormal joint mobility "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: Not Specified

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: Not Specified

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: Not Specified

Allelic Composition: Il6sttm3Thir/Il6sttm3Thir
Genetic Background: Not Specified

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: Not Specified

Allelic Composition: Il6sttm3Thir/Il6sttm3Thir
Genetic Background: Not Specified

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdha1tm1.1Ptl/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6sttm1Thir/Il6sttm1Thir
Genetic Background: involves: 129 * C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il6sttm1Thir/Il6sttm1Thir
Genetic Background: involves: 129 * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: Not Specified

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic Background: involves: 129S1/Sv

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic Background: involves: 129S1/Sv

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Stat3tm1Aki/Stat3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic Background: involves: 129S1/Sv

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic Background: involves: 129S1/Sv

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0009216 abnormal peritoneum morphology "any structural abnormality of the serous sac, consisting of mesothelium and a thin external layer of irregular connective tissue, that lines the abdominopelvic cavity and covers most of the viscera contained therein; it forms two sacs: the peritoneal (or greater) sac and the omental bursa (lesser sac) connected by the omental foramen" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tekt3tm1Zuk/Tekt3tm1Zuk,Tekt4tm1Zuk/Tekt4tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009623 enlarged inguinal lymph nodes "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009631 enlarged axillary lymph nodes "increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig1tm3Dwm/Lig1tm3Dwm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm4Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ifnar2tm1Pjh/Ifnar2tm1Pjh,Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tekt3tm1Zuk/Tekt3tm1Zuk,Tekt4tm1Zuk/Tekt4tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010270 decreased stomach tumor incidence "less than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gkn2tm1.1(KOMP)Vlcg/Gkn2tm1.1(KOMP)Vlcg,Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tg(RP11-H2112)9Trme/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2J

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ino80tm1.1Schg/Ino80+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il6sttm1Ern/Il6st+,Smad3tm1Par/Smad3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gkn2tm1.1(KOMP)Vlcg/Gkn2tm1.1(KOMP)Vlcg,Il6sttm1Ern/Il6sttm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tg(RP11-H2112)5Trme/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2J

Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tg(RP11-H2112)9Trme/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: Not Specified

Allelic Composition: Il6sttm3Thir/Il6sttm3Thir
Genetic Background: Not Specified

Allelic Composition: Il6sttm1Kish/Il6sttm1Kish
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Brca1tm1Cxd/Brca1tm2Cxd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Il6sttm3Thir/Il6sttm3Thir
Genetic Background: Not Specified

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Il6sttm1.1Wme/Il6sttm1.1Wme
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Tekt3tm1Zuk/Tekt3tm1Zuk,Tekt4tm1Zuk/Tekt4tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Tekt3tm1Zuk/Tekt3tm1Zuk,Tekt4tm1Zuk/Tekt4tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex / reaction
 ENSMUSG00000007888 Crlf1 / Q9JM58 / Cytokine receptor-like factor 1 / O75462*  / reaction / complex
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / reaction / complex
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000022146 Osmr / oncostatin M receptor / Q99650*  / complex / reaction
 ENSMUSG00000025746 Il6 / P08505 / interleukin 6 / P05231*  / complex / reaction
 ENSMUSG00000034394 Lif / P09056 / Leukemia inhibitory factor / P15018* / LIF, interleukin 6 family cytokine*  / complex / reaction
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex
 ENSMUSG00000027947 Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*  / reaction / complex
 ENSMUSG00000042340 Ctf1 / Q60753 / Cardiotrophin-1 / Q16619*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000054263 Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*  / complex / reaction
 ENSMUSG00000040663 Clcf1 / Q9QZM3 / Cardiotrophin-like cytokine factor 1 / Q9UBD9*  / reaction / complex
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000058755 Osm / P53347 / Oncostatin-M / P13725*  / reaction / complex
 ENSMUSG00000078735 P70225 / Il11ra2 / Interleukin-11 receptor subunit alpha-2 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*  / reaction / complex
 ENSMUSG00000073889 Q64385 / Il11ra1 / Interleukin-11 receptor subunit alpha-1 / IL11RA* / Q14626* / interleukin 11 receptor subunit alpha*  / reaction / complex
 ENSMUSG00000004371 Il11 / P47873 / Interleukin-11 / P20809*  / reaction / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex / reaction
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000028444 Cntfr / O88507 / Ciliary neurotrophic factor receptor subunit alpha / P26992* / ciliary neurotrophic factor receptor*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000079415 Cntf / P51642 / Ciliary neurotrophic factor / P26441*  / reaction / complex






 

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