ENSMUSG00000042340


Mus musculus

Features
Gene ID: ENSMUSG00000042340
  
Biological name :Ctf1
  
Synonyms : Cardiotrophin-1 / Ctf1 / Q60753
  
Possible biological names infered from orthology : Q16619
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 127712736
Gene end: 127718192
  
Corresponding Affymetrix probe sets: 10557738 (MoGene1.0st)   1449093_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146199
Ensembl peptide - ENSMUSP00000049161
Ensembl peptide - ENSMUSP00000145586
NCBI entrez gene - 13019     See in Manteia.
MGI - MGI:105115
RefSeq - XM_006507316
RefSeq - NM_001301282
RefSeq - NM_001301283
RefSeq - NM_007795
RefSeq Peptide - NP_031821
RefSeq Peptide - NP_001288211
RefSeq Peptide - NP_001288212
swissprot - A0A0U1RNJ2
swissprot - A0A0U1RQ09
swissprot - Q541U3
swissprot - Q60753
Ensembl - ENSMUSG00000042340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTF1ENSG00000150281Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR010681  Plethodontid receptivity factor PRF/cardiotrophin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0048666 neuron development IGI
 biological_processGO:0048861 leukemia inhibitory factor signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005146 leukemia inhibitory factor receptor binding IEA


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000054263 Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*  / complex / reaction






 

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