ENSMUSG00000024789


Mus musculus

Features
Gene ID: ENSMUSG00000024789
  
Biological name :Jak2
  
Synonyms : Jak2 / Janus kinase 2
  
Possible biological names infered from orthology : O60674
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 29251828
Gene end: 29313080
  
Corresponding Affymetrix probe sets: 10462363 (MoGene1.0st)   1421065_at (Mouse Genome 430 2.0 Array)   1421066_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025705
Ensembl peptide - ENSMUSP00000064394
NCBI entrez gene - 16452     See in Manteia.
MGI - MGI:96629
RefSeq - XM_017318068
RefSeq - NM_001048177
RefSeq - NM_008413
RefSeq - XM_006526713
RefSeq - XM_006526714
RefSeq - XM_011247155
RefSeq Peptide - NP_001041642
RefSeq Peptide - NP_032439
swissprot - G5E852
Ensembl - ENSMUSG00000024789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jak2aENSDARG00000104808Danio rerio
 jak2bENSDARG00000018882Danio rerio
 JAK2ENSGALG00000015027Gallus gallus
 JAK2ENSG00000096968Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jak3 / Janus kinase 3 / P52333*ENSMUSG0000003180548
Jak1 / Janus kinase 1 / P23458*ENSMUSG0000002853042
Tyk2 / tyrosine kinase 2 / P29597*ENSMUSG0000003217539


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020693  Tyrosine-protein kinase, non-receptor Jak2
 IPR035588  Janus kinase 2, pseudokinase domain
 IPR035589  Janus kinase 2, catalytic domain
 IPR035860  Tyrosine-protein kinase JAK2, SH2 domain
 IPR035963  FERM superfamily, second domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0031959 mineralocorticoid receptor signaling pathway IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033194 response to hydroperoxide IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0035409 histone H3-Y41 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045822 negative regulation of heart contraction IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050867 positive regulation of cell activation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060396 growth hormone receptor signaling pathway IEA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070671 response to interleukin-12 IEA
 biological_processGO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
 biological_processGO:1904037 positive regulation of epithelial cell apoptotic process IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005131 growth hormone receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0033130 acetylcholine receptor binding IEA
 molecular_functionGO:0035401 histone kinase activity (H3-Y41 specific) IEA
 molecular_functionGO:0042169 SH2 domain binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
Signaling by SCF-KIT
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Cyclin D associated events in G1
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin receptor SHC signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Piwil2tm1.1Doca/Piwil2tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

Allelic Composition: Jak2tm2.2Jlvl/Jak2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jak2tm1Jni/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jak2tm1Jni/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jak2tm1.2Ble/Jak2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Jni/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Jak2tm1.2Ble/Jak2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Aicdatm1Hon/Aicdatm1.1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

Allelic Composition: Jak2tm2.2Jlvl/Jak2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

Allelic Composition: Jak2tm1Jni/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2m1Dlbr/Jak2m1Dlbr
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Jak2m1Dlbr/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst,Tg(Cck-EGFP)BJ203Gsat/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/NTac * Swiss Webster

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tyk2E775K/Tyk2E775K
Genetic Background: B10.D1-H2q/SgJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jak2tm1.2Ble/Jak2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.2Jlvl/Jak2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

Allelic Composition: Jak2tm1Jni/Jak2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aicdatm1Hon/Aicdatm1.1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aicdatm1Hon/Aicdatm1.1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

Allelic Composition: Jak2tm2.2Jlvl/Jak2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL

Allelic Composition: Jak2m1Dlbr/Jak2+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Jak2tm1Jni/Jak2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Aicdatm1Hon/Aicdatm1.1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Jak2tm1.2Ble/Jak2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1(JAK2)Argr/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2m1Dlbr/Jak2+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1.2Ble/Jak2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Jni/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Jak2tm1.1Ble/Jak2tm1.1Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

Allelic Composition: Jak2tm2.1Kpf/Jak2tm2.1Kpf
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Jak2tm1Jni/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Jak2m1Dlbr/Jak2m1Dlbr
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Jak2m1Dlbr/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0011179 decreased erythroblast number "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0011746 spleen fibrosis "invasion of fibrous connective tissue into the spleen, often resulting from inflammation or injury" [MGI:csmith]
Show

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0011747 myelofibrosis "appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8]
Show

Allelic Composition: Jak2tm1Mohi/Jak2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm1Mohi/Jak2tm1Mohi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Jak2tm2.1Jlvl/Jak2+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

 MP:0020399 enhanced megakaryocyte emperipolesis "an increase in the process by which a a megakaryocyte is penetrated by another living cell" [PMID:25654060, PMID:26950939]
Show

Allelic Composition: Jak2tm1.2Ble/Jak2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0030025 giant platelets "presence of abnormally enlarged platelets that are as large as or larger than the red blood cells in the microscopic field; giant platelets may be seen in myeloproliferative and myelodysplastic conditions, autoimmune thrombocytopenia, in association with severe leukemoid reactions, and in rare inherited conditions such as Bernard-Soulier syndrome" [HP:0001902, https://www.labce.com/spg498392_giant_platelets.aspx]
Show

Allelic Composition: Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / reaction / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction / complex
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / reaction / complex
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / reaction / complex
 ENSMUSG00000007888 Crlf1 / Q9JM58 / Cytokine receptor-like factor 1 / O75462*  / complex / reaction
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / reaction / complex
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000005268 Prlr / Q08501 / prolactin receptor / P16471*  / complex / reaction
 ENSMUSG00000020383 Il13 / P20109 / Interleukin-13 / P35225*  / complex / reaction
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / complex
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex / reaction
 ENSMUSG00000042594 Sh2b3 / O09039 / SH2B adapter protein 3 / Q9UQQ2* / SH2B adaptor protein 3*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000004371 Il11 / P47873 / Interleukin-11 / P20809*  / reaction / complex
 ENSMUSG00000054263 Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*  / complex / reaction
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / complex / reaction
 ENSMUSG00000078735 P70225 / Il11ra2 / Interleukin-11 receptor subunit alpha-2 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*  / complex / reaction
 ENSMUSG00000073889 Q64385 / Il11ra1 / Interleukin-11 receptor subunit alpha-1 / IL11RA* / Q14626* / interleukin 11 receptor subunit alpha*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000026288 Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / reaction / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / complex / reaction
 ENSMUSG00000030733 Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*  / complex / reaction
 ENSMUSG00000027947 Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*  / reaction / complex
 ENSMUSG00000058755 Osm / P53347 / Oncostatin-M / P13725*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / reaction / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex / reaction
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / complex / reaction
 ENSMUSG00000025746 Il6 / P08505 / interleukin 6 / P05231*  / complex / reaction
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / reaction / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / complex
 ENSMUSG00000037104 Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*  / complex / reaction
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / reaction / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex / reaction
 ENSMUSG00000049093 Il23r / interleukin 23 receptor / Q5VWK5*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex / reaction
 ENSMUSG00000025383 Il23a / Q9EQ14 / Interleukin-23 subunit alpha / Q9NPF7*  / complex
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / reaction / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / complex / reaction
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / reaction / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000032737 Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*  / reaction / complex
 ENSMUSG00000021948 Prkcd / P28867 / protein kinase C, delta / Q05655*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000022146 Osmr / oncostatin M receptor / Q99650*  / complex / reaction
 ENSMUSG00000034394 Lif / P09056 / Leukemia inhibitory factor / P15018* / LIF, interleukin 6 family cytokine*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / complex / reaction
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / reaction / complex
 ENSMUSG00000042340 Ctf1 / Q60753 / Cardiotrophin-1 / Q16619*  / complex / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000040663 Clcf1 / Q9QZM3 / Cardiotrophin-like cytokine factor 1 / Q9UBD9*  / reaction / complex
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / reaction / complex
 ENSMUSG00000028444 Cntfr / O88507 / Ciliary neurotrophic factor receptor subunit alpha / P26992* / ciliary neurotrophic factor receptor*  / reaction / complex
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / reaction / complex
 ENSMUSG00000079415 Cntf / P51642 / Ciliary neurotrophic factor / P26441*  / complex / reaction






 

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