16452


Mus musculus (NCBI)
regulationbindingsignalingpathwayresponsecellproteinreceptoractivityapoptoticprocessphosphorylationkinasefactorgrowthactivationinterleukin-hormonetyrosineproliferationadhesiondifferentiationinvolvedjak-statcascademuscletumornecrosishistonecellular

Features
Gene ID: 16452
  
Biological name :
  
Synonyms : Fd17 / Jak2 / Janus kinase 2
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1421065_at (Mouse Genome 430 2.0 Array)   1421066_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - XP_017173557.1
RefSeq - 114326478
RefSeq - 114326480
RefSeq - 569006473
RefSeq - 569006475
RefSeq - 569006477
RefSeq - 755562827
RefSeq - NC_000085.6
RefSeq - NP_001041642.1
RefSeq - NP_032439.2
RefSeq - XP_006526776.1
RefSeq - XP_006526777.1
RefSeq - XP_006526778.1
RefSeq - XP_011245457.1
RefSeq - 1039757207
RefSeq - NM_001048177.2
RefSeq - NM_008413.3
RefSeq - XM_011247155.2
RefSeq - XM_017318068.1
RefSeq - XM_006526713.3
RefSeq - XM_006526714.3
RefSeq - XM_006526715.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000024789 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimulusimmune responsecellular component organizationcell deathresponse to stressregulation of biological qualityresponse to chemicalresponse to endogenous stimuluscell adhesionanatomical structure developmentcellular developmental processlocalization of cellmovement of cell or subcellular componentmacromolecule localizationestablishment of localizationresponse to external stimulusresponse to biotic stimuluscytokine productioncellular localizationbiosynthetic processsystem processcell activationmuscle cell proliferationnitrnitrogen compound metabolic processcellcell communicationcellcellular metabolic processprimprimary metabolic processreguregulation of molecular functionorgaorganic substance metabolic processcellcellular response to stimulusimmuimmune responsecellcellular component organizationcellcell deathrespresponse to stressreguregulation of biological qualityrespresponse to chemicalrespresponse to endogenous stimuluscellcell adhesionanatanatomical structure developmentcellcellular developmental processlocalocalization of cellmovemovement of cell or subcellular componentmacrmacromolecule localizationestaestablishment of localizationrespresponse to external stimulusrespresponse to biotic stimuluscytocytokine productioncellcellular localizationbiosbiosynthetic processsystsystem processcellcell activationmuscmuscle cell proliferation
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingcofactor bindingorganic cyclicorganic cyclic compound bindingheterocyclic cheterocyclic compound bindingsmall moleculesmall molecule bindingcatalytic acticatalytic activity, acting on a proteintransferase actransferase activityprotein bindinprotein bindingion bindingion bindingcarbohydrate dcarbohydrate derivative bindingdrug bindingdrug bindingcofactor bindicofactor binding
cellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellorganellemembrane-enclosed lumenmembranecell junctioncellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembranecell junctioncell junction
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity ISO
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0006979 response to oxidative stress ISO
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0007259 JAK-STAT cascade ISO
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress ISO
 biological_processGO:0009755 hormone-mediated signaling pathway ISO
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process ISO
 biological_processGO:0010811 positive regulation of cell-substrate adhesion ISO
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0022408 negative regulation of cell-cell adhesion ISO
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030155 regulation of cell adhesion IBA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0031103 axon regeneration ISO
 biological_processGO:0031959 mineralocorticoid receptor signaling pathway ISO
 biological_processGO:0032024 positive regulation of insulin secretion ISO
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0032731 positive regulation of interleukin-1 beta production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation ISO
 biological_processGO:0033194 response to hydroperoxide ISO
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0034050 host programmed cell death induced by symbiont IDA
 biological_processGO:0034612 response to tumor necrosis factor ISO
 biological_processGO:0035166 post-embryonic hemopoiesis IMP
 biological_processGO:0035409 histone H3-Y41 phosphorylation ISO
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway ISO
 biological_processGO:0036016 cellular response to interleukin-3 IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0042976 activation of Janus kinase activity IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043388 positive regulation of DNA binding ISO
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045597 positive regulation of cell differentiation ISO
 biological_processGO:0045822 negative regulation of heart contraction ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046425 regulation of JAK-STAT cascade IDA
 biological_processGO:0046677 response to antibiotic ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway ISO
 biological_processGO:0050727 regulation of inflammatory response ISO
 biological_processGO:0050729 positive regulation of inflammatory response ISO
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050867 positive regulation of cell activation ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISO
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway ISO
 biological_processGO:0060396 growth hormone receptor signaling pathway ISO
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway ISO
 biological_processGO:0060399 positive regulation of growth hormone receptor signaling pathway IMP
 biological_processGO:0060548 negative regulation of cell death ISO
 biological_processGO:0061180 mammary gland epithelium development IMP
 biological_processGO:0070671 response to interleukin-12 ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 biological_processGO:0097012 response to granulocyte macrophage colony-stimulating factor NAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IDA
 biological_processGO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation ISO
 biological_processGO:1904037 positive regulation of epithelial cell apoptotic process ISO
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation ISO
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0005925 focal adhesion ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005131 growth hormone receptor binding ISO
 molecular_functionGO:0005143 interleukin-12 receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0031702 type 1 angiotensin receptor binding ISO
 molecular_functionGO:0033130 acetylcholine receptor binding ISO
 molecular_functionGO:0035401 histone kinase activity (H3-Y41 specific) ISO
 molecular_functionGO:0042169 SH2 domain binding ISO
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding ISO
 molecular_functionGO:0043560 insulin receptor substrate binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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