ENSMUSG00000073889


Mus musculus

Features
Gene ID: ENSMUSG00000073889
  
Biological name :Il11ra1
  
Synonyms : Il11ra1 / Interleukin-11 receptor subunit alpha-1 / Q64385
  
Possible biological names infered from orthology : IL11RA / interleukin 11 receptor subunit alpha / Q14626
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A5
Gene start: 41699989
Gene end: 41769474
  
Corresponding Affymetrix probe sets: 10504106 (MoGene1.0st)   10512334 (MoGene1.0st)   10512356 (MoGene1.0st)   1417505_s_at (Mouse Genome 430 2.0 Array)   1459868_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095736
Ensembl peptide - ENSMUSP00000103675
Ensembl peptide - ENSMUSP00000103676
Ensembl peptide - ENSMUSP00000103677
NCBI entrez gene - 16157     See in Manteia.
MGI - MGI:107426
RefSeq - NM_001163401
RefSeq - NM_001172054
RefSeq - NM_010549
RefSeq Peptide - NP_001156873
RefSeq Peptide - NP_001165525
RefSeq Peptide - NP_034679
swissprot - Q64385
Ensembl - ENSMUSG00000073889
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il11raENSDARG00000026736Danio rerio
 IL11RAENSGALG00000005848Gallus gallus
 IL11RAENSG00000137070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70225 / Gm13305 / predicted gene 13305 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*ENSMUSG0000007387699
P70225 / Il11ra2 / Interleukin-11 receptor subunit alpha-2 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*ENSMUSG0000007873599
Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*ENSMUSG0000002794725
Cntfr / O88507 / Ciliary neurotrophic factor receptor subunit alpha / P26992* / ciliary neurotrophic factor receptor*ENSMUSG0000002844424
Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*ENSMUSG0000000320615


Protein motifs (from Interpro)
Interpro ID Name
 IPR003530  Long hematopoietin receptor, soluble alpha chain, conserved site
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0032502 developmental process ISS
 biological_processGO:0038154 interleukin-11-mediated signaling pathway IEA
 biological_processGO:0046697 decidualization IMP
 biological_processGO:0060135 maternal process involved in female pregnancy IMP
 biological_processGO:0060322 head development ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004921 interleukin-11 receptor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019970 interleukin-11 binding IPI


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Fmr1tm1Cidz/Fmr1tm1Cidz,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Il11ra1tm1Gos/Il11ra1tm1Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Il11ra1tm1Gos/Il11ra1tm1Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Il11ra1tm1Gos/Il11ra1tm1Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003845 abnormal decidualization "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Il11ra1tm1Gos/Il11ra1tm1Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il11ra1tm1Gos/Il11ra1tm1Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

 MP:0008054 abnormal uterine NK cell morphology "any structural anomaly of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il11ra1tm1Gos/Il11ra1tm1Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0012529 abnormal decidua basalis morphology "any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta" [MGI:anna]
Show

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0012530 abnormal decidua capsularis morphology "any structural anomaly of the layer of uterine endometrium overlying the implanted chorionic vesicle and facing the uterine cavity" [MGI:anna]
Show

Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Il11ra1tm1Wehi/Il11ra1tm1Wehi
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000004371 Il11 / P47873 / Interleukin-11 / P20809*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction






 

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