ENSMUSG00000028444


Mus musculus

Features
Gene ID: ENSMUSG00000028444
  
Biological name :Cntfr
  
Synonyms : Ciliary neurotrophic factor receptor subunit alpha / Cntfr / O88507
  
Possible biological names infered from orthology : ciliary neurotrophic factor receptor / P26992
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 41657498
Gene end: 41697089
  
Corresponding Affymetrix probe sets: 10512279 (MoGene1.0st)   1419429_at (Mouse Genome 430 2.0 Array)   1431663_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100026
Ensembl peptide - ENSMUSP00000100027
Ensembl peptide - ENSMUSP00000115631
NCBI entrez gene - 12804     See in Manteia.
MGI - MGI:99605
RefSeq - XM_017319942
RefSeq - NM_001136056
RefSeq - NM_016673
RefSeq - XM_006537599
RefSeq - XM_011249916
RefSeq - XM_011249917
RefSeq - XM_017319941
RefSeq - XM_006537596
RefSeq - XM_006537597
RefSeq - XM_006537598
RefSeq Peptide - NP_001129528
RefSeq Peptide - NP_057882
swissprot - O88507
swissprot - A2AMR7
Ensembl - ENSMUSG00000028444
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cntfrENSDARG00000028661Danio rerio
 CNTFRENSGALG00000028140Gallus gallus
 CNTFRENSG00000122756Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64385 / Il11ra1 / Interleukin-11 receptor subunit alpha-1 / IL11RA* / Q14626* / interleukin 11 receptor subunit alpha*ENSMUSG0000007388927
P70225 / Il11ra2 / Interleukin-11 receptor subunit alpha-2 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*ENSMUSG0000007873527
P70225 / Gm13305 / predicted gene 13305 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*ENSMUSG0000007387627
Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*ENSMUSG0000002794726
Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*ENSMUSG0000000320617


Protein motifs (from Interpro)
Interpro ID Name
 IPR003530  Long hematopoietin receptor, soluble alpha chain, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IMP
 biological_processGO:0003360 brainstem development IMP
 biological_processGO:0007548 sex differentiation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0060538 skeletal muscle organ development IMP
 biological_processGO:0070120 ciliary neurotrophic factor-mediated signaling pathway ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0070110 ciliary neurotrophic factor receptor complex ISO
 cellular_componentGO:0097059 CNTFR-CLCF1 complex ISO
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004897 ciliary neurotrophic factor receptor activity ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019955 cytokine binding ISO


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000910 small facial motor nucleus "reduced size of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science:ISBN 0-8385-8034-3, J:56847]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0000912 small trigeminal motor nucleus "reduced size of the group of motor neurons innervating the muscles of mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cntfrtm1Lex/Cntfrtm1Lex
Genetic Background: involves: 129S/SvEvBrd

Allelic Composition: Cntfrtm1.1Lex/Cntfrtm1.1Lex
Genetic Background: involves: 129S/SvEvBrd

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cntfrtm1.1Lex/Cntfrtm1.1Lex
Genetic Background: involves: 129S/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000079415 Cntf / P51642 / Ciliary neurotrophic factor / P26441*  / reaction / complex
 ENSMUSG00000054263 Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*  / complex / reaction
 ENSMUSG00000040663 Clcf1 / Q9QZM3 / Cardiotrophin-like cytokine factor 1 / Q9UBD9*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000007888 Crlf1 / Q9JM58 / Cytokine receptor-like factor 1 / O75462*  / reaction / complex






 

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