ENSMUSG00000007888


Mus musculus

Features
Gene ID: ENSMUSG00000007888
  
Biological name :Crlf1
  
Synonyms : Crlf1 / Cytokine receptor-like factor 1 / Q9JM58
  
Possible biological names infered from orthology : O75462
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 70493158
Gene end: 70504081
  
Corresponding Affymetrix probe sets: 10572398 (MoGene1.0st)   1418476_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008032
Ensembl peptide - ENSMUSP00000115614
Ensembl peptide - ENSMUSP00000119545
NCBI entrez gene - 12931     See in Manteia.
MGI - MGI:1340030
RefSeq - XM_006509540
RefSeq - XM_006509541
RefSeq - XM_006509542
RefSeq - NM_018827
RefSeq Peptide - NP_061297
swissprot - Q9JM58
swissprot - F6RP70
swissprot - F6T1W4
Ensembl - ENSMUSG00000007888
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crlf1aENSDARG00000024365Danio rerio
 crlf1bENSDARG00000006368Danio rerio
 CRLF1ENSGALG00000026146Gallus gallus
 CRLF1ENSG00000006016Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prlr / Q08501 / prolactin receptor / P16471*ENSMUSG0000000526819
Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*ENSMUSG0000005573714
Gm21973 / PRLR* / P16471* / prolactin receptor*ENSMUSG000000948142


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015152  Growth hormone/erythropoietin receptor, ligand binding
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:2000672 negative regulation of motor neuron apoptotic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0097058 CRLF-CLCF1 complex TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005127 ciliary neurotrophic factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054263 Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000040663 Clcf1 / Q9QZM3 / Cardiotrophin-like cytokine factor 1 / Q9UBD9*  / reaction / complex
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / complex
 ENSMUSG00000028444 Cntfr / O88507 / Ciliary neurotrophic factor receptor subunit alpha / P26992* / ciliary neurotrophic factor receptor*  / complex / reaction






 

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