Manteia - Molecule gene

ENSMUSG00000005268

Mus musculus

Features

Gene ID:	ENSMUSG00000005268

Biological name :	Prlr

Synonyms :	Prlr / prolactin receptor / Q08501

Possible biological names infered from orthology :	P16471

Species:	Mus musculus

Chr. number:	15
Strand:	1
Band:	A1
Gene start:	10177238
Gene end:	10349180

Corresponding Affymetrix probe sets:	10423030 (MoGene1.0st) 10423049 (MoGene1.0st) 1421382_at (Mouse Genome 430 2.0 Array) 1425853_s_at (Mouse Genome 430 2.0 Array) 1437397_at (Mouse Genome 430 2.0 Array) 1441102_at (Mouse Genome 430 2.0 Array) 1448556_at (Mouse Genome 430 2.0 Array) 1450226_at (Mouse Genome 430 2.0 Array) 1451844_at (Mouse Genome 430 2.0 Array) 1451850_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000121280 Ensembl peptide - ENSMUSP00000121935 Ensembl peptide - ENSMUSP00000122219 Ensembl peptide - ENSMUSP00000122209 Ensembl peptide - ENSMUSP00000116211 Ensembl peptide - ENSMUSP00000117084 Ensembl peptide - ENSMUSP00000118355 Ensembl peptide - ENSMUSP00000120417 NCBI entrez gene - 19116 See in Manteia. MGI - MGI:97763 RefSeq - XM_006520035 RefSeq - XM_006520037 RefSeq - XM_006520034 RefSeq - XM_006520036 RefSeq - NM_001253781 RefSeq - NM_001253782 RefSeq - NM_011169 RefSeq - XM_006520038 RefSeq Peptide - NP_001240711 RefSeq Peptide - NP_001240710 RefSeq Peptide - NP_035299 swissprot - Q08501 swissprot - E9Q631 swissprot - E9Q0U8 swissprot - G3UVW6 swissprot - E9Q2L5 Ensembl - ENSMUSG00000005268

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
prlra	ENSDARG00000016570	Danio rerio
prlrb	ENSDARG00000045955	Danio rerio
PRLR	ENSGALG00000003446	Gallus gallus
PRLR	ENSG00000113494	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*	ENSMUSG00000055737	21
Crlf1 / Q9JM58 / Cytokine receptor-like factor 1 / O75462*	ENSMUSG00000007888	13
Gm21973 / PRLR* / P16471* / prolactin receptor*	ENSMUSG00000094814	9

Protein motifs (from Interpro)

Interpro ID	Name
IPR003528	Long hematopoietin receptor, single chain, conserved site
IPR003961	Fibronectin type III
IPR013783	Immunoglobulin-like fold
IPR015152	Growth hormone/erythropoietin receptor, ligand binding
IPR033230	Prolactin receptor
IPR036116	Fibronectin type III superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	ISO
biological_process	GO:0007259	JAK-STAT cascade	IMP
biological_process	GO:0007595	lactation	IMP
biological_process	GO:0030155	regulation of cell adhesion	IMP
biological_process	GO:0030856	regulation of epithelial cell differentiation	IMP
biological_process	GO:0038161	prolactin signaling pathway	IEA
biological_process	GO:0060644	mammary gland epithelial cell differentiation	IGI
biological_process	GO:0060736	prostate gland growth	IMP
biological_process	GO:0060749	mammary gland alveolus development	IMP
biological_process	GO:0061180	mammary gland epithelium development	IMP
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0009986	cell surface	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004896	cytokine receptor activity	IEA
molecular_function	GO:0004925	prolactin receptor activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0017046	peptide hormone binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Prolactin receptor signaling

Growth hormone receptor signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000367	abnormal coat/ hair morphology	"anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0000427	abnormal hair cycle	"aberrant growth or asynchronous timing of the hair growth " [J:65302]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Prlr^tm1Cnp/Prlr⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0000628	abnormal mammary gland development	"aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl Allelic Composition: Prlr^tm1Cnp/Prlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0000681	abnormal thyroid gland morphology	"anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd79b^m1Ghost/Cd79b^m1Ghost Genetic Background: B10.Cg-Ptprc^a Cd79b^m1Ghost H2^a
MP:0001168	prostate epithelial dysplasia	"abnormal development of the prostate epithelium" [J:63764]	Show Allelic Composition: Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae},Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001346	abnormal lacrimal gland morphology	"malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae},Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001384	abnormal pup retrieval	"a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Prlr^tm1Cnp/Prlr⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0001431	abnormal eating behavior	"inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]	Show Allelic Composition: Kitl^Sl-d/Kitl⁺ Genetic Background: involves: DBA/2J
MP:0001562	abnormal circulating calcium level	"anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0001882	abnormal lactation	"atypical production of milk from the mammary gland" [J:51296]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0001928	abnormal ovulation	"aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0001931	abnormal oogenesis	"atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002566	abnormal sexual interaction	"altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0002832	coarse hair	"hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch" [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:56826]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0002904	increased circulating parathyroid hormone level	"greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0003059	decreased insulin secretion	"less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003212	susceptibility to age related obesity	"increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003845	abnormal decidualization	"disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004014	abnormal uterine environment	"anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0004015	abnormal oviduct environment	"anomaly or inability of the oviduct to support egg viability" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0004016	decreased bone mass	"a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004909	increased seminal gland weight	"increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0004961	increased prostate weight	"greater than average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0005124	increased circulating prolactin level	"greater than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0005181	decreased circulating estradiol level	"less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0005185	decreased circulating progesterone level	"less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0005248	abnormal Harderian gland morphology	"structural anomaly of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005471	decreased thyroxine level	"less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]	Show Allelic Composition: Cd79b^m1Ghost/Cd79b^m1Ghost Genetic Background: B10.Cg-Ptprc^a Cd79b^m1Ghost H2^a
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd79b^m1Ghost/Cd79b^m1Ghost Genetic Background: B10.Cg-Ptprc^a Cd79b^m1Ghost H2^a
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008779	abnormal maternal behavior	"any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Prlr^tm1Cnp/Prlr⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0009114	decreased pancreatic beta cell mass	"reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0009172	small pancreatic islets	"decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0009219	prostate intraepithelial neoplasia	"noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79b^m1Ghost/Cd79b^m1Ghost Genetic Background: B10.Cg-Ptprc^a Cd79b^m1Ghost H2^a
MP:0009287	decreased abdominal fat pad weight	"less than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0009380	abnormal ventral prostate morphology		Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0009967	abnormal neuron proliferation	"any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit,Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010346	increased thyroid carcinioma incidence	"greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79b^m1Ghost/Cd79b^m1Ghost Genetic Background: B10.Cg-Ptprc^a Cd79b^m1Ghost H2^a
MP:0011125	decreased primary ovarian follicle number	"fewer than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:csmith]	Show Allelic Composition: Ddx4^tm1Tnc/Ddx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl
MP:0013476	abnormal Harderian gland porphyrin secretion	"anomaly in the production and/or release of porphyrin(s), the pigment(s) responsible for the red discoloration of ocular and/or nasal discharges in rodents; in rats, protoporhyrin IX accounts for most of the porphyrin produced and stored in the Harderian gland; in some rodents the concentration of porphyrins in the Harderian glands varies according to gender and species, and tends to be higher in females than in males" [http://ratguide.com/health/eyes/porphyrin_secretions_red_tears.php, MGI:Anna]	Show Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000005268	Prlr / Q08501 / prolactin receptor / P16471*	/ reaction / complex
ENSMUSG00000024789	Jak2 / Janus kinase 2 / O60674*	/ complex / reaction
ENSMUSG00000020713	Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...	/ complex / reaction
ENSMUSG00000022400	Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*	/ reaction / complex
ENSMUSG00000029686	Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*	/ reaction / complex
ENSMUSG00000036309	Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*	/ complex / reaction
ENSMUSG00000030733	Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*	/ reaction / complex
ENSMUSG00000025217	Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*	/ complex / reaction

1 s.

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