ENSMUSG00000020713


Mus musculus

Features
Gene ID: ENSMUSG00000020713
  
Biological name :Gh
  
Synonyms : Gh / P06880 / Somatotropin
  
Possible biological names infered from orthology : chorionic somatomammotropin hormone 1 / chorionic somatomammotropin hormone 2 / chorionic somatomammotropin hormone like 1 / CSH1 / CSH2 / CSHL1 / GH1 / GH2 / growth hormone 1 / growth hormone 2 / P01241 / P01242 / P0DML2 / P0DML3 / Q14406
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 106300271
Gene end: 106301865
  
Corresponding Affymetrix probe sets: 10392135 (MoGene1.0st)   1437522_x_at (Mouse Genome 430 2.0 Array)   1456595_x_at (Mouse Genome 430 2.0 Array)   1460310_a_at (Mouse Genome 430 2.0 Array)   1460613_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099360
NCBI entrez gene - 14599     See in Manteia.
MGI - MGI:95707
RefSeq - XM_006532223
RefSeq - NM_008117
RefSeq Peptide - NP_032143
swissprot - P06880
swissprot - A0A0M6L0K7
Ensembl - ENSMUSG00000020713
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gh1ENSDARG00000038185Danio rerio
 GHENSGALG00000000249Gallus gallus
 CSH1ENSG00000136488Homo sapiens
 CSH2ENSG00000213218Homo sapiens
 CSHL1ENSG00000204414Homo sapiens
 GH1ENSG00000259384Homo sapiens
 GH2ENSG00000136487Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core
 IPR018116  Somatotropin hormone, conserved site
 IPR034975  Somatotropin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007405 neuroblast proliferation IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032094 response to food IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0033143 regulation of intracellular steroid hormone receptor signaling pathway ISO
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IGI
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045927 positive regulation of growth IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048513 animal organ development IEA
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0071469 cellular response to alkaline pH IEA
 biological_processGO:0090031 positive regulation of steroid hormone biosynthetic process IEA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005131 growth hormone receptor binding ISO
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Synthesis, secretion, and deacylation of Ghrelin
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0002636 delayed vaginal opening "the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0008330 absent somatotrophs "absence of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0008333 absent lactotrophs "absence of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0008938 decreased pituitary gland weight "reduction in the average weight of the compound gland suspended from the base of the hypothalamus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: GhSma1/Gh+
Genetic Background: C3HeB/FeJ-GhSma1

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0011612 increased circulating ghrelin level "greater than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction / complex
 ENSMUSG00000005268 Prlr / Q08501 / prolactin receptor / P16471*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction / complex
 ENSMUSG00000030733 Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*  / reaction / complex
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / complex / reaction
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / reaction / complex
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / complex / -
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex / reaction






 

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