ENSDARG00000038185


Danio rerio

Features
Gene ID: ENSDARG00000038185
  
Biological name :gh1
  
Synonyms : gh1 / growth hormone 1
  
Possible biological names infered from orthology : chorionic somatomammotropin hormone 1 / chorionic somatomammotropin hormone 2 / chorionic somatomammotropin hormone like 1 / CSH1 / CSH2 / CSHL1 / Gh / GH2 / growth hormone 2 / P01241 / P01242 / P06880 / P0DML2 / P0DML3 / Q14406 / Somatotropin
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 22327738
Gene end: 22332913
  
Corresponding Affymetrix probe sets: DrAffx.2.21.S1_at (Zebrafish Array)   NM_001020492_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000055674
NCBI entrez gene - 407639     See in Manteia.
RefSeq - NM_001020492
RefSeq Peptide - NP_001018328
swissprot - Q1JQ34
ZFIN ID - ZDB-GENE-030725-2
Ensembl - ENSDARG00000038185
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GHENSGALG00000000249Gallus gallus
 CSH1ENSG00000136488Homo sapiens
 CSH2ENSG00000213218Homo sapiens
 CSHL1ENSG00000204414Homo sapiens
 GH1ENSG00000259384Homo sapiens
 GH2ENSG00000136487Homo sapiens
 GhENSMUSG00000020713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smtla / somatolactin alphaENSDARG0000003819123
smtlb / somatolactin betaENSDARG0000001725122


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core
 IPR018116  Somatotropin hormone, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0050996 positive regulation of lipid catabolic process IMP
 biological_processGO:0060612 adipose tissue development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005131 growth hormone receptor binding IMP
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0070186 growth hormone activity IDA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0005345 adipose tissue adipose tissue increased mass , abnormal
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 ZFA:0009082 fat cell fat cell hypertrophic , abnormal
fat cell lipid droplet increased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / reaction / complex
 ENSDARG00000067916 lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / complex / reaction
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSDARG00000038185 gh1 / growth hormone 1 / Gh* / GH2* / CSH2* / CSH1* / CSHL1* / P01242* / Q14406* / P0DML3* / P0DML2* / P01241* / P06880* / Somatotropin * / growth hormone 2* / chorionic somatomammotropin h...  / - / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000057679 sh2b1 / SH2B adaptor protein 1 / Q91ZM2* / Q9NRF2* / SH2B adapter protein 1 *  / reaction / complex
 ENSDARG00000007671 ghrb / growth hormone receptor b / GHR* / P10912* / P16882* / growth hormone receptor* / Growth hormone receptor Growth hormone-binding protein*  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction






 

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