ENSDARG00000104808


Danio rerio

Features
Gene ID: ENSDARG00000104808
  
Biological name :jak2a
  
Synonyms : jak2a / Janus kinase 2a
  
Possible biological names infered from orthology : JAK2 / Janus kinase 2 / O60674
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 249970
Gene end: 294747
  
Corresponding Affymetrix probe sets: Dr.4151.1.S1_at (Zebrafish Array)   NM_131093_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000148034
Ensembl peptide - ENSDARP00000132483
Ensembl peptide - ENSDARP00000143679
NCBI entrez gene - 30307     See in Manteia.
RefSeq - XM_009295057
RefSeq - NM_131093
RefSeq Peptide - NP_571168
swissprot - F1QWX8
ZFIN ID - ZDB-GENE-980526-481
Ensembl - ENSDARG00000104808
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JAK2ENSGALG00000015027Gallus gallus
 JAK2ENSG00000096968Homo sapiens
 Jak2ENSMUSG00000024789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*ENSDARG0000001888267
jak3 / Janus kinase 3 (a protein tyrosine kinase, leukocyte) / P52333* / Janus kinase 3*ENSDARG0000001025247
jak1 / Janus kinase 1 / P23458*ENSDARG0000002062541
tyk2 / tyrosine kinase 2 / P29597*ENSDARG0000002032640


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035588  Janus kinase 2, pseudokinase domain
 IPR035589  Janus kinase 2, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007259 JAK-STAT cascade IMP
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IDA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0060215 primitive hemopoiesis IMP
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
Signaling by SCF-KIT
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
IL-6-type cytokine receptor ligand interactions
Cyclin D associated events in G1
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin receptor SHC signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009044 blood cell blood cell decreased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex / reaction
 ENSDARG00000006368 crlf1b / cytokine receptor-like factor 1b / CRLF1* / O75462* / Q9JM58* / cytokine receptor like factor 1*  / reaction / complex
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000043317 kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex
 ENSDARG00000052157 il12rb2 / interleukin 12 receptor, beta 2a / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000025428 socs3a / suppressor of cytokine signaling 3a / SOCS3* / O14543* / suppressor of cytokine signaling 3*  / complex / reaction
 ENSDARG00000056133 kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSDARG00000026611 socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*  / reaction / complex
 ENSDARG00000067916 lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / reaction / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSDARG00000057679 sh2b1 / SH2B adaptor protein 1 / Q91ZM2* / Q9NRF2* / SH2B adapter protein 1 *  / reaction / complex
 ENSDARG00000038185 gh1 / growth hormone 1 / Gh* / GH2* / CSH2* / CSH1* / CSHL1* / P01242* / Q14406* / P0DML3* / P0DML2* / P01241* / P06880* / Somatotropin * / growth hormone 2* / chorionic somatomammotropin h...  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000028731 stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000074283 inpp5d / inositol polyphosphate-5-phosphatase D / Q92835* / Q9ES52* / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 *  / reaction / complex
 ENSDARG00000024365 crlf1a / cytokine receptor-like factor 1a / CRLF1* / O75462* / Q9JM58* / cytokine receptor like factor 1*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000069958 sh2b3 / SH2B adaptor protein 3 / O09039* / Q9UQQ2* / SH2B adapter protein 3 *  / complex / reaction
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000089043 ptpn6 / protein tyrosine phosphatase, non-receptor type 6 / P29350* / P29351*  / reaction / complex
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000007671 ghrb / growth hormone receptor b / GHR* / P10912* / P16882* / growth hormone receptor* / Growth hormone receptor Growth hormone-binding protein*  / complex / reaction
 ENSDARG00000028661 cntfr / ciliary neurotrophic factor receptor / O88507* / P26992* / Ciliary neurotrophic factor receptor subunit alpha *  / reaction / complex
 ENSDARG00000076140 clcf1 / cardiotrophin-like cytokine factor 1 / Ctf2* / Q9UBD9* / P83714* / Q9QZM3* / Cardiotrophin-2 *  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / reaction / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / reaction / complex
 ENSDARG00000105120 gab2 / GRB2-associated binding protein 2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein family member 4*  / complex
 ENSDARG00000104474 il6r / interleukin 6 receptor / P08887*  / complex / reaction
 ENSDARG00000020326 tyk2 / tyrosine kinase 2 / P29597*  / complex






 

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