ENSDARG00000104693


Danio rerio

Features
Gene ID: ENSDARG00000104693
  
Biological name :il6st
  
Synonyms : il6st / interleukin 6 signal transducer
  
Possible biological names infered from orthology : Interleukin-6 receptor subunit beta / P40189 / Q00560
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 5788620
Gene end: 5821584
  
Corresponding Affymetrix probe sets: Dr.1259.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000130834
Ensembl peptide - ENSDARP00000133294
NCBI entrez gene - 100006778     See in Manteia.
RefSeq - NM_001113504
RefSeq Peptide - NP_001106976
swissprot - F1RCZ2
swissprot - A8WH79
ZFIN ID - ZDB-GENE-080104-6
Ensembl - ENSDARG00000104693
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL6STENSGALG00000014716Gallus gallus
 IL6STENSG00000134352Homo sapiens
 Il6stENSMUSG00000021756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
csf3r / colony stimulating factor 3 receptor (granulocyte) / Q99062* / colony stimulating factor 3 receptor*ENSDARG0000004595919
il12rb2 / interleukin 12 receptor, beta 2a / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*ENSDARG0000005215718
lifra / leukemia inhibitory factor receptor alpha a / LIFR* / P42703* / P42702* / LIF receptor alpha* / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA.*ENSDARG0000009885715
lifrb / leukemia inhibitory factor receptor alpha b / LIFR* / P42703* / P42702* / LIF receptor alpha* / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA.*ENSDARG0000003986315
il12rb2l / interleukin 12 receptor, beta 2a, likeENSDARG0000007485014
osmr / oncostatin M receptorENSDARG0000010073812


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0048680 positive regulation of axon regeneration IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
IL-6-type cytokine receptor ligand interactions
Interleukin-35 Signalling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009280 Muller cell Muller cell cell proliferation decreased process quality , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon regeneration decreased rate , abnormal
retinal ganglion cell axon regeneration decreased process quality , abnormal
retinal ganglion cell axon extension involved in regeneration decreased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex / reaction
 ENSDARG00000006368 crlf1b / cytokine receptor-like factor 1b / CRLF1* / O75462* / Q9JM58* / cytokine receptor like factor 1*  / reaction / complex
 ENSDARG00000052157 il12rb2 / interleukin 12 receptor, beta 2a / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000025428 socs3a / suppressor of cytokine signaling 3a / SOCS3* / O14543* / suppressor of cytokine signaling 3*  / reaction / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSDARG00000026611 socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / reaction / complex
 ENSDARG00000028731 stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSDARG00000024365 crlf1a / cytokine receptor-like factor 1a / CRLF1* / O75462* / Q9JM58* / cytokine receptor like factor 1*  / complex / reaction
 ENSDARG00000028661 cntfr / ciliary neurotrophic factor receptor / O88507* / P26992* / Ciliary neurotrophic factor receptor subunit alpha *  / reaction / complex
 ENSDARG00000020326 tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSDARG00000076140 clcf1 / cardiotrophin-like cytokine factor 1 / Ctf2* / Q9UBD9* / P83714* / Q9QZM3* / Cardiotrophin-2 *  / complex / reaction
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex / reaction
 ENSDARG00000104474 il6r / interleukin 6 receptor / P08887*  / complex / reaction
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction






 

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