ENSDARG00000025428


Danio rerio

Features
Gene ID: ENSDARG00000025428
  
Biological name :socs3a
  
Synonyms : socs3a / suppressor of cytokine signaling 3a
  
Possible biological names infered from orthology : O14543 / O35718 / SOCS3 / suppressor of cytokine signaling 3
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 57423137
Gene end: 57425961
  
Corresponding Affymetrix probe sets: Dr.6431.1.S1_at (Zebrafish Array)   NM_199950_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000038723
NCBI entrez gene - 335409     See in Manteia.
RefSeq - NM_199950
RefSeq Peptide - NP_956244
swissprot - Q7ZUC6
ZFIN ID - ZDB-GENE-030131-7349
Ensembl - ENSDARG00000025428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOCS3ENSGALG00000027786Gallus gallus
 SOCS3ENSG00000184557Homo sapiens
 Socs3ENSMUSG00000053113Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*ENSDARG0000002661168
socs1a / suppressor of cytokine signaling 1a / SOCS1* / O35716* / O15524* / suppressor of cytokine signaling 1*ENSDARG0000003809531
socs1b / suppressor of cytokine signaling 1bENSDARG0000008987329
cishb / cytokine inducible SH2-containing protein b / CISH* / Q62225* / Q9NSE2* / cytokine inducible SH2 containing protein*ENSDARG0000001677329
cish / cytokine inducible SH2-containing protein / Q62225* / Q9NSE2*ENSDARG0000006031628
socs2 / suppressor of cytokine signaling 2 / O14508* / O35717*ENSDARG0000004555726
socs6a / suppressor of cytokine signaling 6a / SOCS6* / O14544* / suppressor of cytokine signaling 6*ENSDARG0000005856525
socs4 / suppressor of cytokine signaling 4ENSDARG0000007850925
socs5b / suppressor of cytokine signaling 5b / SOCS5* / O75159* / O54928* / suppressor of cytokine signaling 5*ENSDARG0000006274524
socs5a / suppressor of cytokine signaling 5a / SOCS5* / O75159* / O54928* / suppressor of cytokine signaling 5*ENSDARG0000010071723
socs6b / suppressor of cytokine signaling 6bENSDARG0000001586323
socs7 / suppressor of cytokine signaling 7 / O14512*ENSDARG0000007701822
socs9 / suppressor of cytokine signaling 9ENSDARG0000010198522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0031099 regeneration IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035677 posterior lateral line neuromast hair cell development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0048681 negative regulation of axon regeneration IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
PTK6 Activates STAT3
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000243 neuromast neuromast has fewer parts of type hair cell , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0009045 epithelial cell of pancreas epithelial cell of pancreas decreased area , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon regeneration increased rate , abnormal
retinal ganglion cell axon regeneration increased process quality , abnormal
retinal ganglion cell axon extension involved in regeneration increased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / reaction / complex
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000104474 il6r / interleukin 6 receptor / P08887*  / complex / reaction
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSDARG00000037980 elob / elongin B / Elobl* / P62869* / Q15370*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSDARG00000045359 elocb / elongin C paralog b / ELOC* / P83940* / Q15369* / elongin C*  / complex
 ENSDARG00000069742 cul5a / cullin 5a / CUL5* / Q93034* / cullin 5*  / complex
 ENSDARG00000004260 cul5b / cullin 5b / CUL5* / Q93034* / cullin 5*  / complex






 

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