ENSG00000184557


Homo sapiens

Features
Gene ID: ENSG00000184557
  
Biological name :SOCS3
  
Synonyms : O14543 / SOCS3 / suppressor of cytokine signaling 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 78356778
Gene end: 78360077
  
Corresponding Affymetrix probe sets: 206359_at (Human Genome U133 Plus 2.0 Array)   206360_s_at (Human Genome U133 Plus 2.0 Array)   214105_at (Human Genome U133 Plus 2.0 Array)   227697_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000330341
Ensembl peptide - ENSP00000464727
NCBI entrez gene - 9021     See in Manteia.
OMIM - 604176
RefSeq - NM_003955
RefSeq Peptide - NP_003946
swissprot - Q6FI39
swissprot - K7EIF6
swissprot - O14543
Ensembl - ENSG00000184557
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs3aENSDARG00000025428Danio rerio
 socs3bENSDARG00000026611Danio rerio
 SOCS3ENSGALG00000027786Gallus gallus
 Socs3ENSMUSG00000053113Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CISH / Q9NSE2 / cytokine inducible SH2 containing proteinENSG0000011473731
SOCS1 / O15524 / suppressor of cytokine signaling 1ENSG0000018533827
SOCS2 / O14508 / suppressor of cytokine signaling 2ENSG0000012083326
SOCS6 / O14544 / suppressor of cytokine signaling 6ENSG0000017067723
SOCS4 / Q8WXH5 / suppressor of cytokine signaling 4ENSG0000018000822
SOCS7 / O14512 / suppressor of cytokine signaling 7ENSG0000027421122
SOCS5 / O75159 / suppressor of cytokine signaling 5ENSG0000017115021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028414  Suppressor of cytokine signalling 3
 IPR035863  SOCS3, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IEA
 biological_processGO:0060674 placenta blood vessel development IEA
 biological_processGO:0060707 trophoblast giant cell differentiation IEA
 biological_processGO:0060708 spongiotrophoblast differentiation IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway TAS
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
Signaling by Leptin
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Neddylation
Interferon alpha/beta signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / complex / reaction
 ENSG00000171855 IFNB1 / P01574 / interferon beta 1  / complex / reaction
 ENSG00000116678 LEPR / P48357 / leptin receptor  / reaction / complex
 ENSG00000112964 GHR / P10912 / growth hormone receptor  / reaction / complex
 ENSG00000136244 IL6 / P05231 / interleukin 6  / reaction / complex
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / reaction / complex
 ENSG00000111537 IFNG / P01579 / interferon gamma  / reaction / complex
 ENSG00000160712 IL6R / P08887 / interleukin 6 receptor  / reaction / complex
 ENSG00000166266 CUL5 / Q93034 / cullin 5  / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000142166 IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1  / reaction / complex
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / reaction / complex
 ENSG00000154582 ELOC / Q15369 / elongin C  / complex
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / complex / reaction
 ENSG00000170581 STAT2 / P52630 / signal transducer and activator of transcription 2  / reaction / complex
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000174697 LEP / leptin / P41159  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / reaction / complex
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / complex / reaction
 ENSG00000159110 IFNAR2 / P48551 / interferon alpha and beta receptor subunit 2  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000103363 ELOB / Q15370 / elongin B  / complex






 

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