ENSG00000100387


Homo sapiens

Features
Gene ID: ENSG00000100387
  
Biological name :RBX1
  
Synonyms : P62877 / RBX1 / ring-box 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.2
Gene start: 40951347
Gene end: 40973309
  
Corresponding Affymetrix probe sets: 218117_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216225
NCBI entrez gene - 9978     See in Manteia.
OMIM - 603814
RefSeq - NM_014248
RefSeq Peptide - NP_055063
swissprot - P62877
Ensembl - ENSG00000100387
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbx1ENSDARG00000038030Danio rerio
 RBX1ENSGALG00000011993Gallus gallus
 Rbx1ENSMUSG00000022400Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RNF7 / Q9UBF6 / ring finger protein 7ENSG0000011412547


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR024766  Zinc finger, RING-H2-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition TAS
 biological_processGO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006293 nucleotide-excision repair, preincision complex stabilization TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010265 SCF complex assembly TAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IPI
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045116 protein neddylation IDA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 cellular_componentGO:0030891 VCB complex IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex IDA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IDA
 cellular_componentGO:0043224 nuclear SCF ubiquitin ligase complex IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019788 NEDD8 transferase activity TAS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:0097602 cullin family protein binding IDA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000166266 CUL5 / Q93034 / cullin 5  / complex
 ENSG00000154767 XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor  / complex / reaction
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / reaction / complex
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / reaction / complex
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / reaction / complex
 ENSG00000144791 LIMD1 / Q9UGP4 / LIM domains containing 1  / complex
 ENSG00000147400 CETN2 / P41208 / centrin 2  / complex / reaction
 ENSG00000154582 ELOC / Q15369 / elongin C  / complex
 ENSG00000148400 NOTCH1 / P46531  / reaction / complex
 ENSG00000036257 CUL3 / Q13618 / cullin 3  / complex
 ENSG00000106571 GLI3 / P10071 / GLI family zinc finger 3  / complex / reaction
 ENSG00000188215 Q8IWE4 / DCUN1D3 / defective in cullin neddylation 1 domain containing 3  / complex / reaction
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / reaction / complex
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / reaction / complex
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / complex / reaction
 ENSG00000119318 P54727 / RAD23B / RAD23 homolog B, nucleotide excision repair protein  / complex / reaction
 ENSG00000155034 FBXL18 / Q96ME1 / F-box and leucine rich repeat protein 18  / complex
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / complex / reaction
 ENSG00000108094 CUL2 / Q13617 / cullin 2  / complex
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / complex / reaction
 ENSG00000134086 VHL / P40337 / von Hippel-Lindau tumor suppressor  / complex
 ENSG00000120696 KBTBD7 / Q8WVZ9 / kelch repeat and BTB domain containing 7  / complex
 ENSG00000111530 CAND1 / Q86VP6 / cullin associated and neddylation dissociated 1  / complex / reaction
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / complex / reaction
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / complex / reaction
 ENSG00000135766 EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1  / complex
 ENSG00000043093 Q96GG9 / DCUN1D1 / defective in cullin neddylation 1 domain containing 1  / complex / reaction
 ENSG00000074047 GLI2 / P10070 / GLI family zinc finger 2  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex / reaction
 ENSG00000225830 ERCC6 / P0DP91 / Q03468 / Q8N328 / ERCC excision repair 6, chromatin remodeling factor  / reaction / complex
 ENSG00000117153 KLHL12 / Q53G59 / kelch like family member 12  / complex
 ENSG00000112659 CUL9 / Q8IWT3 / cullin 9  / complex
 ENSG00000172179 PRL / P01236 / prolactin  / reaction / complex
 ENSG00000103363 ELOB / Q15370 / elongin B  / complex
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000183580 FBXL7 / Q9UJT9 / F-box and leucine rich repeat protein 7  / complex / reaction
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex / reaction
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / reaction / complex
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / reaction / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000131778 CHD1L / Q86WJ1 / chromodomain helicase DNA binding protein 1 like  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000129521 EGLN3 / Q9H6Z9 / egl-9 family hypoxia inducible factor 3  / complex
 ENSG00000134574 DDB2 / Q92466 / damage specific DNA binding protein 2  / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction / complex
 ENSG00000131508 P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2  / reaction
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction / complex
 ENSG00000049167 ERCC8 / Q13216 / ERCC excision repair 8, CSA ubiquitin ligase complex subunit  / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction / complex
 ENSG00000044090 CUL7 / Q14999 / cullin 7  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000109670 FBXW7 / Q969H0 / F-box and WD repeat domain containing 7  / complex
 ENSG00000124006 OBSL1 / O75147 / obscurin like 1  / complex / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / complex / reaction
 ENSG00000169515 CCDC8 / Q9H0W5 / coiled-coil domain containing 8  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / complex
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex
 ENSG00000109332 P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3  / reaction
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / complex
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / complex
 ENSG00000132128 LRRC41 / Q15345 / leucine rich repeat containing 41  / complex
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex
 ENSG00000121022 COPS5 / Q92905 / COP9 signalosome subunit 5  / reaction
 ENSG00000121067 SPOP / O43791 / speckle type BTB/POZ protein  / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / reaction / complex
 ENSG00000143476 DTL / Q9NZJ0 / denticleless E3 ubiquitin protein ligase homolog  / complex
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / reaction / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex
 ENSG00000136936 XPA / P23025 / XPA, DNA damage recognition and repair factor  / reaction / complex
 ENSG00000072401 P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1  / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000239713 Q9HC16 / APOBEC3G / apolipoprotein B mRNA editing enzyme catalytic subunit 3G  / complex / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / complex / reaction






 

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