ENSG00000072401


Homo sapiens

Features
Gene ID: ENSG00000072401
  
Biological name :UBE2D1
  
Synonyms : P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q21.1
Gene start: 58334975
Gene end: 58370753
  
Corresponding Affymetrix probe sets: 211764_s_at (Human Genome U133 Plus 2.0 Array)   214590_s_at (Human Genome U133 Plus 2.0 Array)   215957_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363019
Ensembl peptide - ENSP00000479814
NCBI entrez gene - 7321     See in Manteia.
OMIM - 602961
RefSeq - XM_017016609
RefSeq - NM_001204880
RefSeq - NM_003338
RefSeq Peptide - NP_001191809
RefSeq Peptide - NP_003329
swissprot - A0A024QZJ2
swissprot - A0A087WW00
swissprot - P51668
Ensembl - ENSG00000072401
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2d1bENSDARG00000038576Danio rerio
 UBE2D1ENSGALG00000021213Gallus gallus
 P61080ENSMUSG00000019927Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y2X8 / UBE2D4 / ubiquitin conjugating enzyme E2 D4 (putative)ENSG0000007896792
P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2ENSG0000013150889
P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3ENSG0000010933285
Q96LR5 / UBE2E2 / ubiquitin conjugating enzyme E2 E2ENSG0000018224761
Q969T4 / UBE2E3 / ubiquitin conjugating enzyme E2 E3ENSG0000017003561
P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1ENSG0000017014261
UBE2L5 / ubiquitin conjugating enzyme E2 L5ENSG0000023644439
P68036 / UBE2L3 / ubiquitin conjugating enzyme E2 L3ENSG0000018565138
UBE2S / Q16763 / ubiquitin conjugating enzyme E2 SENSG0000010810637
O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6ENSG0000015658736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:1902916 positive regulation of protein polyubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IDA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
TICAM1, RIP1-mediated IKK complex recruitment
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108733 PEX12 / O00623 / peroxisomal biogenesis factor 12  / reaction / complex
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / reaction
 ENSG00000139197 PEX5 / P50542 / peroxisomal biogenesis factor 5  / complex / reaction
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / reaction
 ENSG00000157911 PEX10 / O60683 / peroxisomal biogenesis factor 10  / complex / reaction
 ENSG00000162928 PEX13 / Q92968 / peroxisomal biogenesis factor 13  / complex / reaction
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / reaction
 ENSG00000142655 PEX14 / O75381 / peroxisomal biogenesis factor 14  / complex / reaction
 ENSG00000164751 PEX2 / P28328 / peroxisomal biogenesis factor 2  / complex / reaction
 ENSG00000167770 OTUB1 / Q96FW1 / OTU deubiquitinase, ubiquitin aldehyde binding 1  / reaction / complex
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction
 ENSG00000134086 VHL / P40337 / von Hippel-Lindau tumor suppressor  / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / complex
 ENSG00000144791 LIMD1 / Q9UGP4 / LIM domains containing 1  / reaction
 ENSG00000135766 EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1  / reaction
 ENSG00000112357 PEX7 / O00628 / peroxisomal biogenesis factor 7  / complex / reaction
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex
 ENSG00000103363 ELOB / Q15370 / elongin B  / reaction
 ENSG00000129521 EGLN3 / Q9H6Z9 / egl-9 family hypoxia inducible factor 3  / reaction
 ENSG00000154582 ELOC / Q15369 / elongin C  / reaction
 ENSG00000108094 CUL2 / Q13617 / cullin 2  / reaction






 

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