ENSG00000109332


Homo sapiens

Features
Gene ID: ENSG00000109332
  
Biological name :UBE2D3
  
Synonyms : P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q24
Gene start: 102794383
Gene end: 102868896
  
Corresponding Affymetrix probe sets: 200667_at (Human Genome U133 Plus 2.0 Array)   200668_s_at (Human Genome U133 Plus 2.0 Array)   200669_s_at (Human Genome U133 Plus 2.0 Array)   223966_at (Human Genome U133 Plus 2.0 Array)   229355_at (Human Genome U133 Plus 2.0 Array)   240383_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422134
Ensembl peptide - ENSP00000422939
Ensembl peptide - ENSP00000481600
Ensembl peptide - ENSP00000427270
Ensembl peptide - ENSP00000426620
Ensembl peptide - ENSP00000426586
Ensembl peptide - ENSP00000425762
Ensembl peptide - ENSP00000424710
Ensembl peptide - ENSP00000424359
Ensembl peptide - ENSP00000423869
Ensembl peptide - ENSP00000423692
Ensembl peptide - ENSP00000423487
Ensembl peptide - ENSP00000423324
Ensembl peptide - ENSP00000318494
Ensembl peptide - ENSP00000337208
Ensembl peptide - ENSP00000337262
Ensembl peptide - ENSP00000344069
Ensembl peptide - ENSP00000345285
Ensembl peptide - ENSP00000349722
Ensembl peptide - ENSP00000378280
Ensembl peptide - ENSP00000378282
Ensembl peptide - ENSP00000378283
Ensembl peptide - ENSP00000396901
Ensembl peptide - ENSP00000421310
Ensembl peptide - ENSP00000421794
Ensembl peptide - ENSP00000421904
NCBI entrez gene - 7323     See in Manteia.
OMIM - 602963
RefSeq - XM_017008584
RefSeq - NM_001300795
RefSeq - NM_003340
RefSeq - NM_181886
RefSeq - NM_181887
RefSeq - NM_181888
RefSeq - NM_181889
RefSeq - NM_181890
RefSeq - NM_181891
RefSeq - NM_181892
RefSeq - NM_181893
RefSeq Peptide - NP_871617
RefSeq Peptide - NP_871618
RefSeq Peptide - NP_871619
RefSeq Peptide - NP_871620
RefSeq Peptide - NP_871621
RefSeq Peptide - NP_871622
RefSeq Peptide - NP_871615
RefSeq Peptide - NP_871616
RefSeq Peptide - NP_001287724
RefSeq Peptide - NP_003331
swissprot - D6R933
swissprot - A0A087WY85
swissprot - H9KV45
swissprot - A0A024RDH2
swissprot - P61077
swissprot - D6RJB3
swissprot - D6RIZ3
swissprot - D6RGD0
swissprot - D6RAW0
swissprot - D6RAH7
swissprot - D6RA11
swissprot - D6R9F6
swissprot - D6R980
Ensembl - ENSG00000109332
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P61079ENSMUSG00000078578Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2ENSG0000013150893
Q9Y2X8 / UBE2D4 / ubiquitin conjugating enzyme E2 D4 (putative)ENSG0000007896787
P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1ENSG0000007240184
Q969T4 / UBE2E3 / ubiquitin conjugating enzyme E2 E3ENSG0000017003560
Q96LR5 / UBE2E2 / ubiquitin conjugating enzyme E2 E2ENSG0000018224760
P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1ENSG0000017014260
UBE2S / Q16763 / ubiquitin conjugating enzyme E2 SENSG0000010810636
UBE2L5 / ubiquitin conjugating enzyme E2 L5ENSG0000023644436
P68036 / UBE2L3 / ubiquitin conjugating enzyme E2 L3ENSG0000018565136
O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6ENSG0000015658733


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IDA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108733 PEX12 / O00623 / peroxisomal biogenesis factor 12  / complex / reaction
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / reaction
 ENSG00000139197 PEX5 / P50542 / peroxisomal biogenesis factor 5  / reaction / complex
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / reaction
 ENSG00000157911 PEX10 / O60683 / peroxisomal biogenesis factor 10  / complex / reaction
 ENSG00000162928 PEX13 / Q92968 / peroxisomal biogenesis factor 13  / reaction / complex
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / reaction
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex
 ENSG00000101695 Q96EQ8 / RNF125 / ring finger protein 125  / complex
 ENSG00000108094 CUL2 / Q13617 / cullin 2  / reaction
 ENSG00000154582 ELOC / Q15369 / elongin C  / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / complex
 ENSG00000134086 VHL / P40337 / von Hippel-Lindau tumor suppressor  / reaction
 ENSG00000164751 PEX2 / P28328 / peroxisomal biogenesis factor 2  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction
 ENSG00000144791 LIMD1 / Q9UGP4 / LIM domains containing 1  / reaction
 ENSG00000129521 EGLN3 / Q9H6Z9 / egl-9 family hypoxia inducible factor 3  / reaction
 ENSG00000112357 PEX7 / O00628 / peroxisomal biogenesis factor 7  / complex / reaction
 ENSG00000142655 PEX14 / O75381 / peroxisomal biogenesis factor 14  / reaction / complex
 ENSG00000103363 ELOB / Q15370 / elongin B  / reaction
 ENSG00000135766 EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1  / reaction






 

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