ENSG00000156587


Homo sapiens

Features
Gene ID: ENSG00000156587
  
Biological name :UBE2L6
  
Synonyms : O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.1
Gene start: 57551656
Gene end: 57568284
  
Corresponding Affymetrix probe sets: 201649_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341980
Ensembl peptide - ENSP00000435265
Ensembl peptide - ENSP00000434348
Ensembl peptide - ENSP00000287156
NCBI entrez gene - 9246     See in Manteia.
OMIM - 603890
RefSeq - NM_198183
RefSeq - NM_004223
RefSeq Peptide - NP_004214
RefSeq Peptide - NP_937826
swissprot - O14933
swissprot - E9PQT7
swissprot - E9PKW8
Ensembl - ENSG00000156587
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9QZU9ENSMUSG00000027078Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBE2L5 / ubiquitin conjugating enzyme E2 L5ENSG0000023644455
P68036 / UBE2L3 / ubiquitin conjugating enzyme E2 L3ENSG0000018565152
P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2ENSG0000013150835
Q9Y2X8 / UBE2D4 / ubiquitin conjugating enzyme E2 D4 (putative)ENSG0000007896735
P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1ENSG0000007240135
P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3ENSG0000010933232
P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1ENSG0000017014232
Q96LR5 / UBE2E2 / ubiquitin conjugating enzyme E2 E2ENSG0000018224731
Q969T4 / UBE2E3 / ubiquitin conjugating enzyme E2 E3ENSG0000017003530
UBE2S / Q16763 / ubiquitin conjugating enzyme E2 SENSG0000010810624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019941 modification-dependent protein catabolic process IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0032020 ISG15-protein conjugation IEA
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019787 ubiquitin-like protein transferase activity IEA
 molecular_functionGO:0042296 ISG15 transferase activity IEA
 molecular_functionGO:0043130 ubiquitin binding EXP


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Negative regulators of DDX58/IFIH1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000101751 POLI / Q9UNA4 / DNA polymerase iota  / reaction / complex
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / reaction / complex
 ENSG00000135945 REV1 / Q9UBZ9 / REV1, DNA directed polymerase  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction / complex
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction / complex
 ENSG00000170142 P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1  / reaction
 ENSG00000181788 SIAH2 / O43255 / siah E3 ubiquitin protein ligase 2  / complex
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000196470 SIAH1 / Q8IUQ4 / siah E3 ubiquitin protein ligase 1  / complex
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / complex / reaction
 ENSG00000145335 SNCA / P37840 / synuclein alpha  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / reaction
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / reaction
 ENSG00000136068 FLNB / O75369 / filamin B  / reaction
 ENSG00000138032 PPM1B / O75688 / protein phosphatase, Mg2+/Mn2+ dependent 1B  / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000170734 POLH / Q9Y253 / DNA polymerase eta  / reaction / complex
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction / complex






 

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