ENSG00000156976


Homo sapiens

Features
Gene ID: ENSG00000156976
  
Biological name :EIF4A2
  
Synonyms : EIF4A2 / eukaryotic translation initiation factor 4A2 / Q14240
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.3
Gene start: 186783205
Gene end: 186789900
  
Corresponding Affymetrix probe sets: 1555996_s_at (Human Genome U133 Plus 2.0 Array)   200912_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398370
Ensembl peptide - ENSP00000462571
Ensembl peptide - ENSP00000415878
Ensembl peptide - ENSP00000413529
Ensembl peptide - ENSP00000407504
Ensembl peptide - ENSP00000402313
Ensembl peptide - ENSP00000326381
Ensembl peptide - ENSP00000388237
Ensembl peptide - ENSP00000392686
NCBI entrez gene - 1974     See in Manteia.
OMIM - 601102
RefSeq - NM_001967
RefSeq Peptide - NP_001958
swissprot - C9JUF0
swissprot - F8WE11
swissprot - J3KSN7
swissprot - E9PBH4
swissprot - Q14240
swissprot - E7EQG2
swissprot - E7EMV8
Ensembl - ENSG00000156976
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4a2ENSDARG00000016477Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1ENSG0000016196090
EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3ENSG0000014154367


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037583  Eukaryotic initiation factor 4A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006446 regulation of translational initiation TAS
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:1900260 negative regulation of RNA-directed 5"-3" RNA polymerase activity IDA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IDA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / reaction
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / complex
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / complex
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / complex
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / complex / reaction
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / complex
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / reaction
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction
 ENSG00000106682 EIF4H / Q15056 / eukaryotic translation initiation factor 4H  / complex
 ENSG00000125977 EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta  / reaction
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / complex
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction






 

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