ENSG00000114867


Homo sapiens

Features
Gene ID: ENSG00000114867
  
Biological name :EIF4G1
  
Synonyms : EIF4G1 / eukaryotic translation initiation factor 4 gamma 1 / Q04637
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.1
Gene start: 184314495
Gene end: 184335358
  
Corresponding Affymetrix probe sets: 208624_s_at (Human Genome U133 Plus 2.0 Array)   208625_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409545
Ensembl peptide - ENSP00000398145
Ensembl peptide - ENSP00000399858
Ensembl peptide - ENSP00000399969
Ensembl peptide - ENSP00000400351
Ensembl peptide - ENSP00000403269
Ensembl peptide - ENSP00000404754
Ensembl peptide - ENSP00000407240
Ensembl peptide - ENSP00000407244
Ensembl peptide - ENSP00000407682
Ensembl peptide - ENSP00000411214
Ensembl peptide - ENSP00000416255
Ensembl peptide - ENSP00000415943
Ensembl peptide - ENSP00000415842
Ensembl peptide - ENSP00000413159
Ensembl peptide - ENSP00000411826
Ensembl peptide - ENSP00000411707
Ensembl peptide - ENSP00000316879
Ensembl peptide - ENSP00000317600
Ensembl peptide - ENSP00000338020
Ensembl peptide - ENSP00000343450
Ensembl peptide - ENSP00000371767
Ensembl peptide - ENSP00000376320
Ensembl peptide - ENSP00000390755
Ensembl peptide - ENSP00000391412
Ensembl peptide - ENSP00000391935
Ensembl peptide - ENSP00000392908
Ensembl peptide - ENSP00000395974
Ensembl peptide - ENSP00000396888
NCBI entrez gene - 1981     See in Manteia.
OMIM - 600495
RefSeq - NM_198242
RefSeq - NM_198241
RefSeq - NM_182917
RefSeq - NM_004953
RefSeq - NM_001291157
RefSeq - NM_001194947
RefSeq - NM_001194946
RefSeq - NM_198244
RefSeq Peptide - NP_001181875
RefSeq Peptide - NP_001181876
RefSeq Peptide - NP_001278086
RefSeq Peptide - NP_004944
RefSeq Peptide - NP_886553
RefSeq Peptide - NP_937884
RefSeq Peptide - NP_937885
RefSeq Peptide - NP_937887
swissprot - F8WCF2
swissprot - H7C044
swissprot - H7C0V6
swissprot - C9JWH7
swissprot - C9JSU8
swissprot - C9JIH5
swissprot - C9JHW9
swissprot - C9JF13
swissprot - C9J987
swissprot - C9J6B6
swissprot - C9J556
swissprot - C9J2Z7
swissprot - Q04637
swissprot - E9PGM1
swissprot - E7EX73
swissprot - E7EUU4
swissprot - C9K073
swissprot - C9JWW9
swissprot - C9JWH9
swissprot - F8WB97
Ensembl - ENSG00000114867
  
Related genetic diseases (OMIM): 614251 - {Parkinson disease 18}, 614251
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01061894.1ENSDARG00000116712Danio rerio
 eif4g1aENSDARG00000006200Danio rerio
 EIF4G1ENSGALG00000008520Gallus gallus
 Eif4g1ENSMUSG00000045983Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3ENSG0000007515148
EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2ENSG0000011032116


Protein motifs (from Interpro)
Interpro ID Name
 IPR003307  W2 domain
 IPR003890  MIF4G-like, type 3
 IPR003891  Initiation factor eIF-4 gamma, MA3
 IPR016024  Armadillo-type fold
 IPR037584  Eukaryotic translation initiation factor 4 gamma 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0002191 cap-dependent translational initiation TAS
 biological_processGO:0006412 translation IPI
 biological_processGO:0006413 translational initiation NAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation NAS
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0010942 positive regulation of cell death IGI
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0031669 cellular response to nutrient levels IMP
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IMP
 biological_processGO:0032502 developmental process TAS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0034645 cellular macromolecule biosynthetic process IGI
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:0080135 regulation of cellular response to stress TAS
 biological_processGO:0097009 energy homeostasis IMP
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP
 biological_processGO:1901215 negative regulation of neuron death TAS
 biological_processGO:1905537 positive regulation of eukaryotic translation initiation factor 4F complex assembly IMP
 biological_processGO:1905606 regulation of presynapse assembly IGI
 biological_processGO:1905612 positive regulation of mRNA cap binding IDA
 biological_processGO:1905618 positive regulation of miRNA mediated inhibition of translation IDA
 biological_processGO:1905696 regulation of polysome binding IMP
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IMP
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex IDA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit TAS
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003743 translation initiation factor activity TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008135 translation factor activity, RNA binding IMP
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding TAS
 molecular_functionGO:0031369 translation initiation factor binding TAS
 molecular_functionGO:0032947 protein-containing complex scaffold activity TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
mTORC1-mediated signalling
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108443 P23443 / RPS6KB1 / ribosomal protein S6 kinase B1  / reaction
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / reaction
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / complex
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / complex / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / complex
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / complex
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / complex / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / complex
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / complex / reaction
 ENSG00000125977 EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta  / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / complex / reaction
 ENSG00000106682 EIF4H / Q15056 / eukaryotic translation initiation factor 4H  / complex
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction






 

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