ENSG00000151247


Homo sapiens

Features
Gene ID: ENSG00000151247
  
Biological name :EIF4E
  
Synonyms : EIF4E / eukaryotic translation initiation factor 4E / P06730
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q23
Gene start: 98871684
Gene end: 98930637
  
Corresponding Affymetrix probe sets: 201435_s_at (Human Genome U133 Plus 2.0 Array)   201436_at (Human Genome U133 Plus 2.0 Array)   201437_s_at (Human Genome U133 Plus 2.0 Array)   237718_at (Human Genome U133 Plus 2.0 Array)   242674_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423977
Ensembl peptide - ENSP00000421287
Ensembl peptide - ENSP00000425561
Ensembl peptide - ENSP00000426602
Ensembl peptide - ENSP00000280892
Ensembl peptide - ENSP00000389624
NCBI entrez gene - 1977     See in Manteia.
OMIM - 133440
RefSeq - XM_006714126
RefSeq - NM_001130678
RefSeq - NM_001130679
RefSeq - NM_001968
RefSeq Peptide - NP_001959
RefSeq Peptide - NP_001124150
RefSeq Peptide - NP_001124151
RefSeq Peptide - NP_001317946
swissprot - X5D7E3
swissprot - P06730
swissprot - D6RBW1
swissprot - D6RFJ3
swissprot - H0Y8J7
Ensembl - ENSG00000151247
  
Related genetic diseases (OMIM): 615091 - {Autism, susceptibility to, 19}, 615091
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4eaENSDARG00000077012Danio rerio
 eif4ebENSDARG00000013274Danio rerio
 EIF4EENSGALG00000042112Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A6NMX2 / EIF4E1B / eukaryotic translation initiation factor 4E family member 1BENSG0000017576657
EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2ENSG0000013593030
EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3ENSG0000016341223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001040  Translation Initiation factor eIF- 4e
 IPR019770  Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
 IPR023398  Translation Initiation factor eIF- 4e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0006405 RNA export from nucleus TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005845 mRNA cap binding complex IDA
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex IDA
 cellular_componentGO:0016442 RISC complex IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000339 RNA cap binding TAS
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003743 translation initiation factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IDA
 molecular_functionGO:0031370 eukaryotic initiation factor 4G binding IDA
 molecular_functionGO:0070491 repressing transcription factor binding IDA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
mTORC1-mediated signalling
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / reaction
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / complex / reaction
 ENSG00000162231 NXF1 / Q9UBU9 / nuclear RNA export factor 1  / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / complex / reaction
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / complex
 ENSG00000106682 EIF4H / Q15056 / eukaryotic translation initiation factor 4H  / complex
 ENSG00000125977 EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta  / reaction
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / complex
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex / reaction
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / complex
 ENSG00000163950 SLBP / Q14493 / stem-loop binding protein  / complex / reaction
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / reaction
 ENSG00000187840 Q13541 / EIF4EBP1 / eukaryotic translation initiation factor 4E binding protein 1  / complex
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction






 

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