ENSG00000173674


Homo sapiens

Features
Gene ID: ENSG00000173674
  
Biological name :EIF1AX
  
Synonyms : EIF1AX / eukaryotic translation initiation factor 1A, X-linked / P47813
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p22.12
Gene start: 20124518
Gene end: 20141844
  
Corresponding Affymetrix probe sets: 201016_at (Human Genome U133 Plus 2.0 Array)   201017_at (Human Genome U133 Plus 2.0 Array)   201018_at (Human Genome U133 Plus 2.0 Array)   201019_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368927
Ensembl peptide - ENSP00000368912
NCBI entrez gene - 107984923     See in Manteia.
NCBI entrez gene - 1964     See in Manteia.
OMIM - 300186
RefSeq - NM_001412
RefSeq Peptide - NP_001403
swissprot - P47813
swissprot - X6RAC9
Ensembl - ENSG00000173674
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif1axaENSDARG00000029003Danio rerio
 eif1axbENSDARG00000057912Danio rerio
 EIF1AYENSGALG00000016410Gallus gallus
 BB287469ENSMUSG00000079031Mus musculus
 Eif1aENSMUSG00000057561Mus musculus
 Eif1axENSMUSG00000067194Mus musculus
 Gm16368ENSMUSG00000114075Mus musculus
 Gm2016ENSMUSG00000072905Mus musculus
 Gm2022ENSMUSG00000113971Mus musculus
 Gm2035ENSMUSG00000096619Mus musculus
 Gm2056ENSMUSG00000095717Mus musculus
 Gm2075ENSMUSG00000096049Mus musculus
 Gm21319ENSMUSG00000095724Mus musculus
 Gm21936ENSMUSG00000113201Mus musculus
 Gm4027ENSMUSG00000092019Mus musculus
 Gm5039ENSMUSG00000093847Mus musculus
 Gm5662ENSMUSG00000079029Mus musculus
 Gm5788ENSMUSG00000113805Mus musculus
 Gm6803ENSMUSG00000096803Mus musculus
 Gm8300ENSMUSG00000079034Mus musculus
 Gm8332ENSMUSG00000095799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF1AY / O14602 / eukaryotic translation initiation factor 1A, Y-linkedENSG0000019869299


Protein motifs (from Interpro)
Interpro ID Name
 IPR001253  Translation initiation factor 1A (eIF-1A)
 IPR006196  RNA-binding domain, S1, IF1 type
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018104  Translation initiation factor 1A (eIF-1A), conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / reaction
 ENSG00000106682 EIF4H / Q15056 / eukaryotic translation initiation factor 4H  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000125977 EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta  / reaction / complex
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / reaction / complex
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / reaction
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / reaction / complex






 

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