ENSG00000070756


Homo sapiens

Features
Gene ID: ENSG00000070756
  
Biological name :PABPC1
  
Synonyms : P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q22.3
Gene start: 100685816
Gene end: 100722809
  
Corresponding Affymetrix probe sets: 1560770_at (Human Genome U133 Plus 2.0 Array)   215157_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429119
Ensembl peptide - ENSP00000429594
Ensembl peptide - ENSP00000429790
Ensembl peptide - ENSP00000429892
Ensembl peptide - ENSP00000430012
Ensembl peptide - ENSP00000430159
Ensembl peptide - ENSP00000430716
Ensembl peptide - ENSP00000478108
Ensembl peptide - ENSP00000428840
Ensembl peptide - ENSP00000428937
Ensembl peptide - ENSP00000428948
Ensembl peptide - ENSP00000429032
Ensembl peptide - ENSP00000429395
Ensembl peptide - ENSP00000313007
Ensembl peptide - ENSP00000427805
Ensembl peptide - ENSP00000427914
Ensembl peptide - ENSP00000428021
Ensembl peptide - ENSP00000428030
Ensembl peptide - ENSP00000428190
Ensembl peptide - ENSP00000428749
NCBI entrez gene - 26986     See in Manteia.
OMIM - 604679
RefSeq - NM_002568
RefSeq - XM_005250861
RefSeq Peptide - NP_002559
swissprot - H0YBN4
swissprot - A0A024R9C1
swissprot - A0A087WTT1
swissprot - E5RFD8
swissprot - E5RGC4
swissprot - E5RGH3
swissprot - E5RH24
swissprot - E5RHG7
swissprot - E5RJB9
swissprot - E5RJM8
swissprot - E7EQV3
swissprot - E7ERJ7
swissprot - H0YAP2
swissprot - H0YAR2
swissprot - H0YAS6
swissprot - H0YAS7
swissprot - H0YAW6
swissprot - H0YB75
swissprot - H0YB86
swissprot - H0YC10
swissprot - P11940
Ensembl - ENSG00000070756
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pabpc1aENSDARG00000017219Danio rerio
 pabpc1bENSDARG00000021140Danio rerio
 PABPC1ENSGALG00000030280Gallus gallus
 Pabpc2ENSMUSG00000051732Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PABPC3 / Q9H361 / poly(A) binding protein cytoplasmic 3ENSG0000015184692
PABPC4 / Q13310 / poly(A) binding protein cytoplasmic 4ENSG0000009062178
Q4VXU2 / PABPC1L / poly(A) binding protein cytoplasmic 1 likeENSG0000010110468
P0CB38 / PABPC4L / poly(A) binding protein cytoplasmic 4 likeENSG0000025453542
PABPC5 / Q96DU9 / poly(A) binding protein cytoplasmic 5ENSG0000017474038
Q5JQF8 / PABPC1L2A / poly(A) binding protein cytoplasmic 1 like 2AENSG0000018628825
Q5JQF8 / PABPC1L2B / poly(A) binding protein cytoplasmic 1 like 2BENSG0000018438825
RBMS1 / P29558 / RNA binding motif single stranded interacting protein 1ENSG0000015325017
RBMS3 / Q6XE24 / RNA binding motif single stranded interacting protein 3ENSG0000014464217
RBMS2 / Q15434 / RNA binding motif single stranded interacting protein 2ENSG0000007606716
PUF60 / Q9UHX1 / poly(U) binding splicing factor 60ENSG0000017995014
ELAVL4 / P26378 / ELAV like RNA binding protein 4ENSG0000016237413
ELAVL2 / Q12926 / ELAV like RNA binding protein 2ENSG0000010710513
ELAVL3 / Q14576 / ELAV like RNA binding protein 3ENSG0000019636112
ELAVL1 / Q15717 / ELAV like RNA binding protein 1ENSG0000006604411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002004  Polyadenylate-binding protein/Hyperplastic disc protein
 IPR003954  RNA recognition motif domain, eukaryote
 IPR006515  Polyadenylate binding protein, human types 1, 2, 3, 4
 IPR035979  RNA-binding domain superfamily
 IPR036053  PABC (PABP) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0000398 mRNA splicing, via spliceosome IC
 biological_processGO:0006378 mRNA polyadenylation TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0048255 mRNA stabilization TAS
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
 biological_processGO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008143 poly(A) binding IDA
 molecular_functionGO:0008266 poly(U) RNA binding IDA
 molecular_functionGO:0008494 translation activator activity TAS


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130741 EIF2S3 / P41091 / eukaryotic translation initiation factor 2 subunit gamma  / reaction
 ENSG00000134001 EIF2S1 / P05198 / eukaryotic translation initiation factor 2 subunit alpha  / reaction
 ENSG00000063046 EIF4B / P23588 / eukaryotic translation initiation factor 4B  / reaction
 ENSG00000106682 EIF4H / Q15056 / eukaryotic translation initiation factor 4H  / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / complex
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / complex
 ENSG00000125977 EIF2S2 / P20042 / eukaryotic translation initiation factor 2 subunit beta  / reaction
 ENSG00000173674 EIF1AX / P47813 / eukaryotic translation initiation factor 1A, X-linked  / reaction






 

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