ENSGALG00000030280


Gallus gallus

Features
Gene ID: ENSGALG00000030280
  
Biological name :PABPC1
  
Synonyms : PABPC1 / polyadenylate-binding protein 1
  
Possible biological names infered from orthology : P11940 / P29341 / PABPC3 / poly(A) binding protein cytoplasmic 1 / poly(A) binding protein cytoplasmic 3 / Q9H361
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 129199347
Gene end: 129213966
  
Corresponding Affymetrix probe sets: Gga.4666.1.S1_s_at (Chicken Array)   GgaAffx.9197.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045369
Ensembl peptide - ENSGALP00000063445
Ensembl peptide - ENSGALP00000063216
Ensembl peptide - ENSGALP00000061037
Ensembl peptide - ENSGALP00000057021
NCBI entrez gene - 430997     See in Manteia.
RefSeq - NM_001031597
RefSeq Peptide - NP_001026768
swissprot - A0A1L1RQG9
swissprot - A0A1L1RX80
swissprot - A0A1D5NYB2
swissprot - A0A1D5PVP6
swissprot - A0A1L1RWK3
Ensembl - ENSGALG00000030280
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pabpc1aENSDARG00000017219Danio rerio
 pabpc1bENSDARG00000021140Danio rerio
 P11940ENSG00000070756Homo sapiens
 PABPC3ENSG00000151846Homo sapiens
 P29341ENSMUSG00000022283Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q13310* / P0CB38* / PABPC4* / PABPC4L* / poly(A) binding protein cytoplasmic 4* / poly(A) binding protein cytoplasmic 4 like*ENSGALG0000000380079
PABPC1L / poly(A) binding protein cytoplasmic 1 like / Q4VXU2*ENSGALG0000000412374
RBMS1 / RNA binding motif single stranded interacting protein 1 / P29558* / Q91W59*ENSGALG0000001113216
RBMS2 / RNA binding motif single stranded interacting protein 2 / Q15434* / Q8VC70*ENSGALG0000003875715
PUF60 / poly(U)-binding-splicing factor PUF60 / Q3UEB3* / Q9UHX1* / poly(U) binding splicing factor 60*ENSGALG0000003990114
ELAVL2 / ELAV like RNA binding protein 2 / Q12926* / Q60899* / Mus musculus ELAV like RNA binding protein 1 (Elavl2), transcript variant 5, mRNA.*ENSGALG0000001579913
ELAVL4 / ELAV-like protein 4 / P26378* / Q61701* / ELAV like RNA binding protein 4* / Mus musculus ELAV like RNA binding protein 4 (Elavl4), transcript variant 5, mRNA.*ENSGALG0000001053313
ELAVL1 / ELAV-like protein 1 / P70372* / Q15717* / ELAV like RNA binding protein 1*ENSGALG0000000072611
RBMS3 / RNA binding motif single stranded interacting protein 3 / Q6XE24* / Q8BWL5* / RNA binding motif, single stranded interacting protein*ENSGALG0000001143911
ENSGALG000000382597


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002004  Polyadenylate-binding protein/Hyperplastic disc protein
 IPR003954  RNA recognition motif domain, eukaryote
 IPR006515  Polyadenylate binding protein, human types 1, 2, 3, 4
 IPR012677  Nucleotide-binding alpha-beta plait domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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