ENSDARG00000017219


Danio rerio

Features
Gene ID: ENSDARG00000017219
  
Biological name :pabpc1a
  
Synonyms : pabpc1a / poly(A) binding protein, cytoplasmic 1a
  
Possible biological names infered from orthology : P11940 / P29341 / PABPC1 / Pabpc2 / PABPC3 / Pabpc6 / poly(A) binding protein cytoplasmic 1 / poly(A) binding protein cytoplasmic 3 / Polyadenylate-binding protein 1 / Q9H361
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 54829284
Gene end: 54851247
  
Corresponding Affymetrix probe sets: Dr.12233.1.S1_at (Zebrafish Array)   Dr.12233.1.S2_a_at (Zebrafish Array)   Dr.12233.2.S1_x_at (Zebrafish Array)   NM_001031676_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000021064
Ensembl peptide - ENSDARP00000124828
NCBI entrez gene - 606498     See in Manteia.
RefSeq - NM_001031676
RefSeq - XM_005169771
RefSeq Peptide - NP_001026846
swissprot - F1QB54
ZFIN ID - ZDB-GENE-030131-3238
Ensembl - ENSDARG00000017219
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PABPC1ENSGALG00000030280Gallus gallus
 P11940ENSG00000070756Homo sapiens
 PABPC3ENSG00000151846Homo sapiens
 P29341ENSMUSG00000022283Mus musculus
 Pabpc2ENSMUSG00000051732Mus musculus
 Pabpc6ENSMUSG00000046173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pabpc1b / poly A binding protein, cytoplasmic 1 b / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...ENSDARG0000002114092
pabpc4 / poly(A) binding protein, cytoplasmic 4 (inducible form) / Q13310* / P0CB38* / PABPC4L* / poly(A) binding protein cytoplasmic 4* / poly(A) binding protein cytoplasmic 4 like*ENSDARG0000005925977
pabpc1l / poly(A) binding protein, cytoplasmic 1-like / Q4VXU2*ENSDARG0000000259771
rbms3 / RNA binding motif, single stranded interacting protein / Q6XE24* / Q8BWL5* / RNA binding motif single stranded interacting protein 3*ENSDARG0000004457416
rbms1a / RNA binding motif, single stranded interacting protein 1a / RBMS1* / Q91W59* / P29558* / RNA binding motif single stranded interacting protein 1*ENSDARG0000007402316
rbms2b / RNA binding motif, single stranded interacting protein 2b / RBMS2* / Q8VC70* / Q15434* / RNA binding motif single stranded interacting protein 2*ENSDARG0000005615015
rbms2a / RNA binding motif, single stranded interacting protein 2a / RBMS2* / Q8VC70* / Q15434* / RNA binding motif single stranded interacting protein 2*ENSDARG0000004417914
puf60a / poly-U binding splicing factor a / PUF60* / Q3UEB3* / Q9UHX1* / poly(U) binding splicing factor 60* / Poly(U)-binding-splicing factor PUF60 *ENSDARG0000003217513
Q6IQE0 / puf60b / poly-U binding splicing factor b / PUF60* / Q3UEB3* / Q9UHX1* / poly(U) binding splicing factor 60* / Poly(U)-binding-splicing factor PUF60 *ENSDARG0000000124113
elavl4 / ELAV like neuron-specific RNA binding protein 4 / P26378* / Q61701* / ELAV like RNA binding protein 4* / Mus musculus ELAV like RNA binding protein 4 (Elavl4), transcript variant 5, mRNA.*ENSDARG0000004563912
elavl2 / ELAV like neuron-specific RNA binding protein 2 / Q12926* / Q60899* / ELAV like RNA binding protein 2* / Mus musculus ELAV like RNA binding protein 1 (Elavl2), transcript variant 5, mRNA.*ENSDARG0000004073212
elavl1b / ELAV like RNA binding protein 1b / Q15717* / P70372* / ELAVL1* / ELAV-like protein 1 * / ELAV like RNA binding protein 1*ENSDARG0000010174411
elavl1a / ELAV like RNA binding protein 1a / Q15717* / P70372* / ELAVL1* / ELAV-like protein 1 * / ELAV like RNA binding protein 1*ENSDARG0000003869511
elavl3 / ELAV like neuron-specific RNA binding protein 3 / Q60900* / Q14576* / ELAV-like protein 3 * / ELAV like RNA binding protein 3*ENSDARG0000001442011
RBMS1 (1 of many) / RNA binding motif single stranded interacting protein 1 / RBMS1* / P29558*ENSDARG000001038239


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002004  Polyadenylate-binding protein/Hyperplastic disc protein
 IPR003954  RNA recognition motif domain, eukaryote
 IPR006515  Polyadenylate binding protein, human types 1, 2, 3, 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007507 heart development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain quality , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
midbrain hindbrain boundary decreased thickness , abnormal
Show

 ZFA:0000084 yolk yolk quality , abnormal
yolk circular , abnormal
yolk grey , abnormal
Show

 ZFA:0000106 extension extension decreased thickness , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle distended , abnormal
Show

 ZFA:0000471 atrium atrium dilated , abnormal
Show

 ZFA:0001094 whole organism whole organism polysome decreased amount , abnormal
whole organism morphology , abnormal
whole organism viability , abnormal
whole organism necrotic , abnormal
whole organism decreased pigmentation , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042252 eif4h / eukaryotic translation initiation factor 4h / Q15056* / Q9WUK2*  / reaction
 ENSDARG00000005827 eif2s1a / eukaryotic translation initiation factor 2, subunit 1 alpha a / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / reaction
 ENSDARG00000052178 eif2s1b / eukaryotic translation initiation factor 2, subunit 1 alpha b / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / reaction
 ENSDARG00000003032 eif4a1b / eukaryotic translation initiation factor 4A1B / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / reaction
 ENSDARG00000092115 eif4a1a / eukaryotic translation initiation factor 4A1A / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / reaction
 ENSDARG00000016477 eif4a2 / eukaryotic translation initiation factor 4A, isoform 2 / P10630* / Q14240* / eukaryotic translation initiation factor 4A2* / Mus musculus eukaryotic translation initiation factor 4...  / reaction
 ENSDARG00000008292 eif2s3 / F1QGW6 / eukaryotic translation initiation factor 2, subunit 3 gamma / Q9Z0N2* / P41091* / Q2VIR3* / Q9Z0N1* / EIF2S3B* / Eif2s3x* / Eif2s3y* / eukaryotic translation initiation fa...  / reaction
 ENSDARG00000014898 ncbp2 / Q8JGR6 / nuclear cap binding protein subunit 2 / Q9CQ49* / NCBP2L* / P52298* / A6PVI3* / nuclear cap binding protein subunit 2 like*  / complex
 ENSDARG00000057912 eif1axb / eukaryotic translation initiation factor 1A, X-linked, b / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction
 ENSDARG00000029003 eif1axa / eukaryotic translation initiation factor 1A, X-linked, a / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr