ENSDARG00000003032


Danio rerio

Features
Gene ID: ENSDARG00000003032
  
Biological name :eif4a1b
  
Synonyms : eif4a1b / eukaryotic translation initiation factor 4A1B
  
Possible biological names infered from orthology : EIF4A1 / Eukaryotic initiation factor 4A-I / eukaryotic translation initiation factor 4A1 / P60842 / P60843
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 24208413
Gene end: 24219344
  
Corresponding Affymetrix probe sets: Dr.11824.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000018923
NCBI entrez gene - 399484     See in Manteia.
swissprot - Q7ZU67
ZFIN ID - ZDB-GENE-040120-6
Ensembl - ENSDARG00000003032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EIF4A1ENSG00000161960Homo sapiens
 Eif4a1ENSMUSG00000059796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eif4a1a / eukaryotic translation initiation factor 4A1A / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*ENSDARG0000009211593
eif4a2 / eukaryotic translation initiation factor 4A, isoform 2 / P10630* / Q14240* / eukaryotic translation initiation factor 4A2* / Mus musculus eukaryotic translation initiation factor 4...ENSDARG0000001647792
eif4a3 / eukaryotic translation initiation factor 4A3 / P38919*ENSDARG0000010297865


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006413 translational initiation IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005827 eif2s1a / eukaryotic translation initiation factor 2, subunit 1 alpha a / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / reaction
 ENSDARG00000038585 eif4e2 / eif4e2rs1 / eukaryotic translation initiation factor 4E family member 2 / O60573*  / reaction
 ENSDARG00000077215 eif4g3a / eukaryotic translation initiation factor 4 gamma, 3a / O43432* / EIF4G3* / eukaryotic translation initiation factor 4 gamma 3* / Mus musculus eukaryotic translation initiation fac...  / complex
 ENSDARG00000015835 eif4e2rs1 / eukaryotic translation initiation factor 4E family member 2 related sequence 1  / reaction
 ENSDARG00000003616 arih1 / Q6PFJ9 / ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) / Q9Z1K5* / Q9Y4X5* / E3 ubiquitin-protein ligase ARIH1 * / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction
 ENSDARG00000005078 eif4e3 / Q66HY7 / eukaryotic translation initiation factor 4E family member 3 / Q9DBB5* / Q8N5X7* / Eukaryotic translation initiation factor 4E type 3 *  / complex
 ENSDARG00000086374 isg15 / ISG15 ubiquitin-like modifier / P05161* / Q64339* / Ubiquitin-like protein ISG15 *  / reaction
 ENSDARG00000036870 arih1l / Q6NW85 / ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 like / ARIH1* / Q9Z1K5* / Q9Y4X5* / E3 ubiquitin-protein ligase ARIH1 * / ariadne RBR E3 ubiquitin prot...  / reaction
 ENSDARG00000008292 eif2s3 / F1QGW6 / eukaryotic translation initiation factor 2, subunit 3 gamma / Q9Z0N2* / P41091* / Q2VIR3* / Q9Z0N1* / EIF2S3B* / Eif2s3x* / Eif2s3y* / eukaryotic translation initiation fa...  / reaction
 ENSDARG00000017219 pabpc1a / poly(A) binding protein, cytoplasmic 1a / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...  / reaction
 ENSDARG00000021140 pabpc1b / poly A binding protein, cytoplasmic 1 b / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...  / reaction
 ENSDARG00000052178 eif2s1b / eukaryotic translation initiation factor 2, subunit 1 alpha b / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / reaction
 ENSDARG00000057912 eif1axb / eukaryotic translation initiation factor 1A, X-linked, b / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction
 ENSDARG00000029003 eif1axa / eukaryotic translation initiation factor 1A, X-linked, a / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction
 ENSDARG00000016477 eif4a2 / eukaryotic translation initiation factor 4A, isoform 2 / P10630* / Q14240* / eukaryotic translation initiation factor 4A2* / Mus musculus eukaryotic translation initiation factor 4...  / complex
 ENSDARG00000042252 eif4h / eukaryotic translation initiation factor 4h / Q15056* / Q9WUK2*  / complex






 

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