ENSMUSG00000059796


Mus musculus

Features
Gene ID: ENSMUSG00000059796
  
Biological name :Eif4a1
  
Synonyms : Eif4a1 / Eukaryotic initiation factor 4A-I / P60843
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 4A1 / P60842
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69666936
Gene end: 69672423
  
Corresponding Affymetrix probe sets: 10346780 (MoGene1.0st)   10387545 (MoGene1.0st)   10387557 (MoGene1.0st)   10466402 (MoGene1.0st)   1427058_at (Mouse Genome 430 2.0 Array)   1430980_a_at (Mouse Genome 430 2.0 Array)   1434985_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099649
Ensembl peptide - ENSMUSP00000127034
NCBI entrez gene - 13681     See in Manteia.
MGI - MGI:95303
RefSeq - NM_001159375
RefSeq - NM_144958
RefSeq Peptide - NP_001152847
RefSeq Peptide - NP_659207
swissprot - Q5F2A7
swissprot - P60843
swissprot - K3W4Q6
Ensembl - ENSMUSG00000059796
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4a1aENSDARG00000092115Danio rerio
 eif4a1bENSDARG00000003032Danio rerio
 EIF4A1ENSG00000161960Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif4a2 / P10630 / Mus musculus eukaryotic translation initiation factor 4A2 (Eif4a2), transcript variant 5, mRNA.ENSMUSG0000002288490
Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*ENSMUSG0000002558067
Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*ENSMUSG0000009497366
Gm5580 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*ENSMUSG0000010790666


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037583  Eukaryotic initiation factor 4A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Deadenylation of mRNA
Ribosomal scanning and start codon recognition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000093661 Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*  / complex
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / complex
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000026254 Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*  / reaction






 

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