ENSMUSG00000093661


Mus musculus

Features
Gene ID: ENSMUSG00000093661
  
Biological name :Eif4e3
  
Synonyms : Eif4e3 / Eukaryotic translation initiation factor 4E type 3 / Q9DBB5
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 4E family member 3 / Q8N5X7
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D3
Gene start: 99625135
Gene end: 99666771
  
Corresponding Affymetrix probe sets: 10546685 (MoGene1.0st)   1417977_at (Mouse Genome 430 2.0 Array)   1417978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032151
NCBI entrez gene - 66892     See in Manteia.
MGI - MGI:1914142
RefSeq - NM_025829
RefSeq Peptide - NP_080105
swissprot - Q9DBB5
Ensembl - ENSMUSG00000093661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4e3ENSDARG00000005078Danio rerio
 EIF4E3ENSGALG00000007780Gallus gallus
 EIF4E3ENSG00000163412Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif4e / P63073 / Eukaryotic translation initiation factor 4E ENSMUSG0000002815627
Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*ENSMUSG0000002625427
Q3UTA9 / Eif4e1b / Eukaryotic translation initiation factor 4E type 1B / A6NMX2* / eukaryotic translation initiation factor 4E family member 1B*ENSMUSG0000007489524


Protein motifs (from Interpro)
Interpro ID Name
 IPR001040  Translation Initiation factor eIF- 4e
 IPR023398  Translation Initiation factor eIF- 4e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005845 mRNA cap binding complex ISS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000026254 Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*  / reaction
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / complex
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000059796 Eif4a1 / P60843 / Eukaryotic initiation factor 4A-I / P60842* / eukaryotic translation initiation factor 4A1*  / complex
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction






 

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