ENSMUSG00000026254


Mus musculus

Features
Gene ID: ENSMUSG00000026254
  
Biological name :Eif4e2
  
Synonyms : Eif4e2 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / Q8BMB3
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 4E family member 2 / O60573
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 87213914
Gene end: 87240488
  
Corresponding Affymetrix probe sets: 10348180 (MoGene1.0st)   1421985_a_at (Mouse Genome 430 2.0 Array)   1421986_at (Mouse Genome 430 2.0 Array)   1435803_a_at (Mouse Genome 430 2.0 Array)   1435804_at (Mouse Genome 430 2.0 Array)   1455108_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108859
Ensembl peptide - ENSMUSP00000108858
Ensembl peptide - ENSMUSP00000108861
Ensembl peptide - ENSMUSP00000137771
Ensembl peptide - ENSMUSP00000053403
Ensembl peptide - ENSMUSP00000075699
Ensembl peptide - ENSMUSP00000108856
Ensembl peptide - ENSMUSP00000108857
NCBI entrez gene - 26987     See in Manteia.
MGI - MGI:1914440
RefSeq - XM_006529674
RefSeq - NM_001039169
RefSeq - NM_001039170
RefSeq - NM_001347083
RefSeq - NM_023314
RefSeq - XM_006529669
RefSeq - XM_006529670
RefSeq - XM_006529671
RefSeq - XM_006529673
RefSeq Peptide - NP_001034258
RefSeq Peptide - NP_001034259
RefSeq Peptide - NP_001334012
RefSeq Peptide - NP_075803
swissprot - D3Z730
swissprot - G3X9H1
swissprot - M0QWD1
swissprot - D3Z729
swissprot - Q0P688
swissprot - Q3UUT0
swissprot - Q8BMB3
swissprot - D3YUV9
Ensembl - ENSMUSG00000026254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4e2ENSDARG00000038585Danio rerio
 EIF4E2ENSGALG00000007919Gallus gallus
 EIF4E2ENSG00000135930Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif4e / P63073 / Eukaryotic translation initiation factor 4E ENSMUSG0000002815630
Q3UTA9 / Eif4e1b / Eukaryotic translation initiation factor 4E type 1B / A6NMX2* / eukaryotic translation initiation factor 4E family member 1B*ENSMUSG0000007489527
Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*ENSMUSG0000009366123


Protein motifs (from Interpro)
Interpro ID Name
 IPR001040  Translation Initiation factor eIF- 4e
 IPR019770  Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
 IPR023398  Translation Initiation factor eIF- 4e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0017148 negative regulation of translation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005845 mRNA cap binding complex IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / reaction
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / complex / reaction
 ENSMUSG00000093661 Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*  / reaction
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / reaction
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000059796 Eif4a1 / P60843 / Eukaryotic initiation factor 4A-I / P60842* / eukaryotic translation initiation factor 4A1*  / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / complex / reaction






 

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